Shiv Bahadur

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ETHNOPHARMACOLOGICAL RELEVANCE Trikatu is a very well known 'Rasayana' in Ayurveda and widely used as a polyherbal ayurvedic formulation in India. It consists of three well known plants, viz., Piper longum (PL), Piper nigrum (PN) and Zingiber officinale (ZO) in equal ratio. Trikatu has been prescribed for cough, cold, fever, asthma, respiratory problems and(More)
ETHNOPHARMACOLOGICAL RELEVANCE An Ayurvedic herb, Swertia chirata (SC) have been used in treating various ailments such as hyperglycemia, leishmania, liver infections, inflammation, abdominal pain, bacterial infection, malaria etc. in Indian Systems of Medicine (ISM). AIM OF THE STUDY Study was designed to investigate the inhibition potential of the(More)
The present study was aimed to develop a catechin (CA) loaded nanoemulsion based nano-gel for the protection of skin against ultraviolet radiation (UV) induced photo-damage and to ensure its enhanced skin permeability as well as bioavailability through transdermal route. The optimized nanoemulsion (CA-NE4) was prepared by spontaneous nano-emulsification(More)
OBJECTIVE The seeds of Trigonella foenum-graecum (TFG) (family: Leguminosae) are widely consumed both as a spice in food and Traditional Medicine in India. The present study was undertaken to evaluate the inhibitory effect of standardized extract of TFG and its major constituent trigonelline (TG) on rat liver microsome (RLM) and cytochrome P450 (CYP450)(More)
AIMS The study was aimed to develop a ferulic acid (FA) loaded nanoemulsion based gel in order to ensure the enhanced permeability and maximum antioxidant activity against UVA induced oxidative stress in rat. MAIN METHODS The optimized ferulic acid loaded nanoemulsion 3 (FA-NE3) was prepared by spontaneous nano-emulsification method with an appropriate(More)
ETHNOPHARMACOLOGICAL RELEVANCE Ayurveda entails a scientific tradition of harmonious living and its origin can be traced from ancient knowledge in Rigveda and Atharvaveda. Ayurveda is a traditional healthcare system of Indian medicine since ancient times. Several Ayurvedic medicines have been exploiting for treatment and management of various diseases in(More)
BACKGROUND Andrographis paniculata, Bacopa monnieri and Centella asiatica are mentioned in Ayurveda for the management of neurodegenerative disorders. These plants and their phytomolecules, such as andrographolide, bacoside A and asiaticoside, were studied for their inhibition potential on pooled CYP450 as well as human CYP3A4, CYP2D6, CYP2C9 and CYP1A2 by(More)
In the present study, possible cytochrome enzyme inhibition potential of Aegle marmelos (L.) Corrêa fruit and its bioactive compound was evaluated. Interaction potential of Aegle marmelos extract was evaluated through CYP450carbonmonoxide complex (CYP450-CO) assay. Additionally, influence on individual major human cytochrome P450 drug metabolizing enzymes(More)
The development of traditional medicine with the perspectives of safety, efficacy and quality would help not only to preserve the traditional heritage but also to rationalize the use of herbal medicine in the human healthcare. Nature is considered as a compendium for templates of new chemical entities. The medicinal plants mentioned in the different ancient(More)
Secondary metabolites from plants provide lead molecules for drug development. Metabolomics is a modern omic-technique for comprehensive analysis of phytochemicals. Advances in mass spectrometry (MS) based platforms like GC-MS and LC-MS, helped in separation and identification of several metabolites. Such analysis can be a valuable tool for identifying(More)