Shisheng Li

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Covalent modifications of proteins by ubiquitin and the Small Ubiquitin-like MOdifier (SUMO) have been revealed to be involved in a plethora of cellular processes, including transcription, DNA repair and DNA damage responses. It has been well known that in response to DNA damage that blocks transcription elongation, Rpb1, the largest subunit of RNA(More)
Spt5, a transcription elongation factor, and Rpb4, a subunit of RNA polymerase II (RNAP II) that forms a subcomplex with Rpb7, play important roles in transcription elongation and repression of transcription coupled DNA repair (TCR) in eukaryotic cells. How Spt5 physically interacts with RNAP II, and if and/or how Spt5 and Rpb4/7 coordinate to achieve the(More)
Dynamic typing is a barrier for JavaScript applications to achieve high performance. Compared with statically typed languages, the major overhead of dynamic typing comes from runtime type resolution and runtime property lookup. Common folks' belief is that the traditional static compilation techniques are no longer effective for dynamic languages. The best(More)
  • Christoph Lahtz, Sang-In Kim, Steven E Bates, Arthur X Li, Xiwei Wu, Gerd P Pfeifer +2 others
  • 2013
Unprotected exposure to UVB radiation from the sun and the resulting DNA damage are thought to be responsible for physiological changes in the skin and for a variety of skin cancers, including basal cell and squamous cell carcinoma and malignant melanoma. Although the mutagenic effects of UVB have been well documented and studied mechanistically, there is(More)