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To investigate the pathogenesis of localized autoimmune damage in Sjögren's syndrome (SS) by examining the expression patterns of cytokines, chemokines and chemokine receptors at sites of autoimmune damage. mRNA expression of these molecules in the labial salivary glands (LSGs) and peripheral blood mononuclear cells (PBMCs) from 36 SS patients was examined(More)
OBJECTIVE Heightened interest in oral health has lead to an increase in patients complaining of xerostomia, which is associated with various oral mucosal disorders. In this study, we investigated the relationship between Candida species and oral mucosal disorders in patients with xerostomia. SUBJECTS AND METHODS We evaluated whole salivary flow rate and(More)
The aim of this study was to investigate the initiation and progression of autoimmune damage in the lesions of labial salivary glands (LSGs) from primary Sjögren's syndrome (SS) patients by examining the selective localization of T helper (Th) subsets such as Th1, Th2, Th17 regulatory T cells (T(regs)) and follicular T helper cells (Tfh). The expression of(More)
We examined the effects of continuous intravenous infusion of nitroglycerin (NTG) on lung dysfunction induced by endotoxemia in awake sheep chronically instrumented with lung lymph fistula. We measured the responses of hemodynamics, lung lymph balance, and thromboxane (Tx)B2 and 6-keto-prostaglandin (PG) Fla levels in plasma and lung lymph to endotoxin(More)
In the recent gyrotron development in JT-60U ECRF system, output power of 1.5 MW for 1 s has been achieved at 110 GHz. It is the world highest power oscillation in the range of > 1 s. In addition to the carefully designed cavity and collector in view of thermal stress, an RF shield for the adjustment bellows, and a low-dielectric-loss DC break enabled this(More)
We examined, in isolated blood perfused rat lungs, the effect of the cell permeable 8-bromo derivative of cGMP on pulmonary vasoconstriction induced by either alveolar hypoxia or angiotensin II. 8-Bromo cGMP dose-dependently reduced both hypoxia-(IC50=2.2 × 10−5 M) and angiotensin-II-induced pulmonary vasoconstriction (IC50=5.0 × 10−5 M). This effect of(More)
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