Shiro Hosoda

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This study was undertaken to investigate the effect of epidermal growth factor (EGF) on the rat small intestinal mucosa by three different routes of administration. Four-week-old rats were fed elemental diet for 4 weeks and were administered EGF either subcutaneously, intraluminally or intraperitoneally with mini-osmotic pumps for a week. Intraperitoneal(More)
This study was undertaken to evaluate the effect of epidermal growth factor (EGF) on the morphological changes and polyamine metabolism in the atrophic small intestinal mucosa of rats caused by feeding elemental diet (ED; Elental®, Ajinomoto, Tokyo) for several weeks. Four-week-old Wistar male rats were given ad libitum ED (1 kcal/ml) for 4 weeks. The body(More)
To investigate the role played by cytokines in chronic pancreatitis, we examined serum levels of interleukin-1β (IL-1β) and interleukin-6 (IL-6) by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) in 33 patients with definitively diagnosed chronic pancreatitis. All the patients, who had received either no treatment or only digestive(More)
The effects of cholecystokinin octapeptide (CCK8) on amino acid transport and protein synthesis in the pancreatic acini were determined. The question of whether those effects differed between amino acid transport systems A and L was also investigated. The influx of α-[3H]aminoisobutyric acid (AIB, system A) and [14C]cycloleucine (system L) into isolated rat(More)
In order to disclose the mechanisms involving the elevation of serum 5′-nucleotidase (5′-N) activity in viral hepatitis patients, 5′-N activities in sera and liver tissues were examined in acute and chronic hepatitis patients and compared with normal controls. Serum 5′-N activities were 0.714±0.106 nanomoles adenosine/hour/mg protein in normal individuals,(More)
This study investigated the influence of extracellular matrix on growth and secretory function associated with cholecystokinin (CCK) receptors in pancreatic acinar AR42J cells, using reconstituted basement membrane derived from Engelbreth-Holm-Swarm (EHS) tumor. The cells were cultured with basement membranes of two different thicknesses, 1 mg/ml protein(More)
In order to clarify the relationship between the cause of death in acute strangulated intestinaI obstruction and intestinal microorganisms, especially E. coli group, small strangulated intestinal obstruction was established to the germfree mice and at the same time lipopolysaccharide endotoxin of the E. eoli was also injected into the strangulated(More)