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Norepinephrine-glucocorticoids interaction does not annul the opposite effects of the individual treatments on cellular plasticity in neuroblastoma cells.
The plasticity hypothesis of major depression states that glucocorticoids may be detrimental to neuronal plasticity while monoamines and antidepressants may reconstitute cellular plasticity. The aimExpand
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Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action.
Norepinephrine (NE) and glucocorticoids (GCs) have been shown to oppositely affect various aspects of neuronal plasticity. These findings provided the basis for the plasticity hypothesis of majorExpand
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Prenatal heroin exposure alters cholinergic receptor stimulated activation of the PKCβII and PKCγ isoforms
Abstract Prenatal exposure of mice to heroin (SC injection of 10 mg/kg to the dams on gestational days 9–18) resulted at adulthood in behavioral deficits related to septohippocampal cholinergicExpand
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