Shiow-Hwa Day

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A new lignan glycoside, 4-O-alpha-L-arabinopyranosyl-(1' "-->2' ')-beta-D-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4)(More)
Effects of K(+)- and Cl(-)-channel blockers on the muscle contraction of mouse diaphragm in response to direct electrical muscle stimulation were studied. K(+)-channel blockers (0.1-1 mmol/l 4-aminopyridine, 0.4-1.2 mmol/l uranyl nitrate and 2-30 mmol/l tetraethylammonium chloride) and a Cl(-)-channel blocker (0.01-0.03 mmol/l 9-anthracene carboxylic acid)(More)
The Enclosed Magill, Humphrey ADE and the Bain breathing systems are all used for controlled ventilation of the lungs. This study compares the three systems in vitro with a lung model and in clinical practice. No difference was observed, with ventilatory variables commonly used in clinical practice, between the Bain and the ADE, while significantly lower(More)
In the rabbit blood stream, plasminogen circulates as two glycoforms, plasminogen I (PLG-I) and plasminogen II (PLG-II), in a molar ratio of 1:2.2. To compare their relative behaviors toward a site of vascular injury, radiolabeled samples of PLG-I and PLG-II were coinjected intravenously into NZW rabbits before inducing a de-endothelializing (balloon(More)
The bradycardia produced by 1 microgram acetylcholine in the isolated perfused rabbit heart, in the presence of vecuronium and atracurium, was studied and compared with control. Vecuronium at a concentration of 2.5 micrograms/litre and atracurium 6 micrograms/litre did not enhance the negative chronotropic effect of acetylcholine. Atracurium produced a(More)
The present study has shown that the human placenta (first trimester and full term) contains a significant population of mononuclear cells (isolated by proteolytic treatment) expressing receptors for Fc(IgG) and C3 and bearing surface immunoglobulin that is probably cytophilic. The cells, as assessed by morphology, resemble macrophages and actively partake(More)
A monoclonal antibody (I8B/A5) was generated towards human first-trimester purified trophoblast plasma membrane which, unlike others reported in the literature, reacted only against cytotrophoblast but not against syncytiotrophoblast. However, this antibody cross-reacted with certain fetal epithelial and endothelial surfaces in a well-defined manner. On(More)
One new diterpene, 8(14),15-sandaracopimaradiene-2alpha,3beta,18-triol (1), two new phenylpropane derivatives, i.e., (E)-methyl 2-(3,4-methylene-dioxyphenyl)-3-methoxypropenoate (2) and (E)-2-(3,4-methylene-dioxyphenyl)-3-methoxypropenoic acid (3), and two known diterpenes, ent-8(14),15-sandaracopimaradiene-2alpha,18-diol (4) and(More)
  • Y W Loke, S Day
  • 1984
A monoclonal antibody (18B/A5) has been generated against human first trimester trophoblast membranes which, unlike others so far reported in the literature, reacted only with cytotrophoblast and not with syncytiotrophoblast. Although the identity of the target antigen has not yet been established, the antibody could be a valuable tool for the(More)
Plasminogen (PLG) exists in the circulation as two glycoforms, I and II. Angiostatin (AST) is a polypeptide that has been cleaved from the kringle region of PLG and has strong anti-angiogenic properties. AST-I and AST-II, which consisted only of kringles 1 through 3, were prepared by the action of urokinase on purified rabbit PLG-I and PLG-II, respectively,(More)