Shiori Kuraoka

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Cl- current in gamma-aminobutyric acid (GABA)-sensitive neurons of the frog dorsal root ganglia was separated from other ionic components (i.e., Na+, Ca2+, and K+ currents) using a suction pipette technique, which allowed internal perfusion and current clamp. The GABA-induced depolarization response increased slightly on substituting Na+ by(More)
Imidafenacin is a potent and selective antagonist of M1 and M3 muscarinic receptors that is safe, efficacious, and well tolerated for controlling the symptoms of overactive bladder (OAB). However, the precise mechanisms responsible for the bladder-selective pharmacological effects of this agent remain unclear. The in vivo pharmacologic effects of(More)
The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed. Transdermal administration of oxybutynin in rats leads to significant binding of muscarinic receptors in the bladder without long-term binding in the(More)
The actions of organic and inorganic Ca2+-antagonists on an inactivation of the Ca2+ channel was studied in molluscan neurones using a suction pipette technique. Both Ca2+-antagonists decreased the peak amplitude of Ca2+ current (ICa). The organic Ca2+-antagonists verapamil and diltiazem hastened the decay of ICa, while the inorganic Ca2+-antagonists Co2+(More)
The inhibitory action of divalent metal cations and diltiazem, an organic Ca2+ channel blocker, on the divalent cation currents through Ca2+ channels (DCCs) was studied in a molluscan neuron using a suction pipette technique. The time course of the inhibitory action of divalent cations on the maximum peak amplitude (MPA) of DCCs was more rapid than that of(More)
The permeability to various cations of the voltage-dependent sodium channel of rat single heart cells has been studied under the current or voltage clamp conditions. The cells, dispersed by collagenase treatment, were perfused internally using a suction pipette technique. The permeability sequence, estimated from the effects of various cations on the(More)
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