Shinzo Kobayashi

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Purpose. The transport of peptides or proteins across the alveolar cell monolayer was studied in vitro in order to elucidate their transport pathway. Methods. The permeability of 14 peptides or proteins and 6 dextrans with MW 1,000~150,000 was measured in cultured human lung adenocarcinoma A549 cell monolayers at 37°C or 4°C. The stability of the tested(More)
Purpose. To evaluate the effects of absorption enhancers in dry powders and in liquids, pulmonary absorption of salmon calcitonin (sCT) in various formulations was measured. Methods. The dry powder of sCT was prepared by a freeze-drying method with a jet mill. After intratracheal administration of sCT dry powder and liquid (solution) preparations to rats,(More)
Effects of protease inhibitors and absorption enhancers on the absorption of salmon calcitonin (sCT) were evaluated after intratracheal coadministration to rats using the plasma Ca level as an index. Remarkable absorption enhancement could be attained with unsaturated fatty acids such as oleic acid and polyoxyethylene oleyl ether (absorption enhancers) and(More)
Large-Scale Online Course (LSOC) requires stable and low-cost services and special learning and teaching methods because numerous learners are generally studying on a course for free. This paper proposes Learning Support System (LSS) using e-book with an access management federation designed for LSOC. The proposed LSS reaches the solution to a flipped(More)
Online education has provided good opportunities for educationally disadvantaged people. However, some traditional learning management systems (LMSs), the base systems of online education, had the limitations in offering standardized education for diversified learners with different skills, objectives, abilities, preferences, and backgrounds. In addition,(More)
An optically active helical poly(phenylacetylene) was synthesized by the copolymerization of phenylacetylenes bearing optically active hydroxy or ester groups obtained by the kinetic resolution of a racemic phenylacetylene with lipase; the helix-sense was inverted from one helix to another by the further chemical modification of the hydroxy groups with(More)
A facile method for synthesizing diverse optically active polymers with different backbone structures was developed by the polymerization of an optically active aromatic azide bearing an acetylene unit with a rhodium catalyst followed by the click reaction of the pendant azides or by the click polymerization of the monomer.