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PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel
PIKfyve phosphorylates PtdIns(3)P to PtdIns(3, 5)P2. One of the best characterized effector downstream of PtdIns(3, 5)P2 is a lysosomal Ca2+ channel, TRPML1. Although it has been reported that TRPML1… Expand
Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning.
- Shinya Takemasu, K. Nigorikawa, +4 authors K. Hazeki
- Chemistry, Medicine
- Journal of biochemistry
- 1 August 2019
TMEM55B is first identified as phosphatidylinositol-4,5-P24-phosphatases (PtdIns-4,5-P24-phosphatases) that catalyse dephosphorylation of PtdIns-4,5-P2 to PtdIns-5-P. We demonstrate for the first… Expand