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STUDY DESIGN Retrospective study of 66 patients who underwent laminoplasty for treatment of cervical myelopathy due to ossification of the posterior longitudinal ligament (OPLL). OBJECTIVES The present study describes surgical results of laminoplasty for treatment of cervical myelopathy due to OPLL and aims to clarify 1) factors predicting outcome and 2)(More)
The purpose of this retrospective study was to demonstrate the surgical outcomes of anterior spinal fusion (ASF) and posterior subtraction osteotomy (PSO) for osteoporotic vertebral collapse (OVC). Forty patients who underwent surgery for OVC at the thoracolumbar junction with neurological deficits were included in this study. ASF was primarily chosen for(More)
STUDY DESIGN Retrospective study. OBJECTIVE We sought to determine the long-term outcomes of laminoplasty versus anterior decompression and fusion in the treatment of cervical myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) and to ascertain what factors should be considered in selecting appropriate surgical procedure. (More)
STUDY DESIGN A retrospective case-control study. OBJECTIVE To clarify associations between both lamina horizontalization and facet tropism and adjacent segment degeneration (ASD). SUMMARY OF BACKGROUND DATA We have previously reported coexistence of lamina horizontalization and facet tropism adjacent to the cranial fusion segment as risk factors for(More)
INTRODUCTION Surgical strategy for thoracic disc herniation (TDH) remains controversial. We have performed posterior thoracic interbody fusion (PTIF) by bilateral total facetectomies with pedicle screw fixation. The objectives of this retrospective study are to demonstrate the surgical outcomes of PTIF for TDH. MATERIALS AND METHODS We enrolled 11(More)
STUDY DESIGN A retrospective study of 87 patients who underwent posterior lumbar interbody fusion (PLIF) at L4-L5 for L4 degenerative spondylolisthesis. OBJECTIVE To clarify: 1) the correlation between radiologic degeneration of cranial adjacent segment and clinical results, 2) risk factors for radiologic degeneration of cranial adjacent segment, and 3)(More)
STUDY DESIGN Apoptosis in cervical intervertebral disc cells and cartilaginous endplate cells was examined by the nick end labeling (TUNEL) technique during the process of natural aging and in a mouse experimental spondylosis model. OBJECTIVES To determine the role of apoptosis in aging and degeneration of intervertebral discs by monitoring chronologic(More)
STUDY DESIGN Localization of cathepsins D, K, and L in degenerated intervertebral discs was examined by immunohistochemistry. OBJECTIVES To determine the involvement of cathepsins in the pathomechanism of intervertebral disc degeneration by monitoring the immunolocalization of cathepsins in degenerated intervertebral disc tissue. SUMMARY OF BACKGROUND(More)
STUDY DESIGN Various amounts of static mechanical load were applied to mouse intervertebral discs in organ cultures. The apoptosis then was examined using nick end labeling. Two mitogen-activated protein kinase (MAPK) inhibitors were added to the medium. OBJECTIVES To establish an experimental model for detecting factors regulating chondrocyte apoptosis(More)
STUDY DESIGN Age-related fluctuations in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells were investigated. OBJECTIVES The purpose of this study was to determine whether synthetic responses to insulin-like growth factor-I decline with age and to explore the possibility that an age-related increase in the(More)