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We evaluated the clinical efficacy of endonasal endoscopic sinus surgery (ESS) in patients with asthma associated with chronic sinusitis. Twenty-one patients (13 men and 8 women) from 27 to 72 years old were enrolled in this study. All patients had had sinus-related symptoms for more than 3 months and had computed tomographic evidence of paranasal sinus(More)
Endothelial and epithelial adhesion molecules are important in the recruitment of leukocytes to inflammatory sites. To determine the relationship between recruited leukocytes and adhesion molecules in the paranasal sinus mucosa of nonallergic chronic sinusitis, we surgically obtained mucosa from 16 patients and identified the expression of intercellular(More)
BACKGROUND The mechanism of neutrophil recruitment in patients with chronic sinusitis is unclear. OBJECTIVE This study aims to elucidate the role of IL-8 in inducing neutrophil accumulation in the nasal discharge of patients with chronic sinusitis. METHODS Nasal discharge and mucosal specimens were obtained from two groups of patients, those with(More)
During the past 2 years, drug-induced interstitial pneumonia was reported in 66 Japanese patients, mainly among chronic hepatitis C patients, undergoing treatment with the Japanese herbal medicine "Sho-saiko-to" (TJ-9). As interstitial pneumonia is also induced by granulocyte colony-stimulating factor (G-CSF), we examined the effects of TJ-9 on G-CSF(More)
PURPOSE Previously, we suggested that alkylglucoside can be an effective vector for renal-specific drug delivery (Suzuki et al., J. Pharmacol. Exp. Ther, 288:57-61, 1999). The purpose of the present study is to characterize the membrane protein which is recognized by this alkylglucoside. METHODS The binding of [125I] tyrosine conjugated with a(More)
PURPOSE We have previously shown Glc-S-C7-Me (octyl beta-D-thioglucoside) exhibits renal targeting potential in vivo in addition to its specific binding to the renal membrane fraction in vitro. Thus, "alkylglycoside" is considered to be a novel targeting vector for the kidney (1,2). The present study is designed to clarify the structural requirements for(More)
We present a 73-year-old female with an enlarged mass in the right parotid gland. Fine-needle aspiration cytology suggested pleomorphic adenoma. Diagnostic imaging revealed that the tumour had a well-defined margin arising from the deep lobe of the parotid gland. A total parotidectomy with preservation of the facial nerve was performed. The final(More)
We studied the efficacy of high-dose steroid therapy for severe sudden deafness, and evaluated various factors that affect hearing recovery; i.e., severity of hearing loss, age, presence of vertigo and time to the beginning treatment. Twenty-eight patients with idiopathic sudden sensorineural hearing loss whose hearing levels were 60 dB or more were(More)