Shintaro Tachibana

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BACKGROUND In the absence of thromboprophylaxis, patients undergoing total hip arthroplasty (THA) are at increased risk for venous thromboembolism (VTE). The objective of this study was to compare the efficacy and safety of edoxaban with enoxaparin for the prevention of VTE after THA in Japan. METHODS This was a phase 3, double-blind, double-dummy,(More)
BACKGROUND Edoxaban is an oral, direct, factor Xa inhibitor approved in Japan for thromboembolic prophylaxis after lower-limb orthopedic surgery (LLOS), but contraindicated in patients with severe renal impairment (SRI; creatinine clearance [CLCR] ≥15 to <30 mL/min). METHODS This open-label study compared the safety of edoxaban 15 mg once daily in(More)
solated palsy of the posterior interosseous nerve (PIN) can occur without nerve compression and is often referred to as isolated neuritis or neuralgic amyotro-phy because of its characteristic elbow pain at the onset, lasting days to weeks with subsequent weakness. The diagnosis is based on the clinical course because, to our knowledge, there have been no(More)
BACKGROUND The objective of this analysis was to assess the effects of edoxaban compared with enoxaparin on key coagulation biomarkers and present pooled primary efficacy and safety results from phase 3 STARS E-3 and STARS J-V trials for prevention of venous thromboembolism (VTE) after total knee arthroplasty (TKA) or total hip arthroplasty (THA). METHODS(More)
BACKGROUND Guidelines from the Japanese Circulation Society recommend prophylaxis with anticoagulation plus intermittent pneumatic compression or graduated compression stockings (GCS) among patients at the highest risk for developing venous thromboembolism (VTE). However, the benefits of concomitant GCS use for patients undergoing total knee arthroplasty(More)
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