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- Publications
- Influence
Morphological and Functional Changes in the Retina after Chronic Oxygen-Induced Retinopathy
- Shinsuke Nakamura, S. Imai, Hiromi Ogishima, K. Tsuruma, M. Shimazawa, H. Hara
- Chemistry, Medicine
- PloS one
- 14 February 2012
The mouse model of oxygen-induced retinopathy (OIR) has been widely used for studies of retinopathy of prematurity (ROP). This disorder, characterized by abnormal vascularization of the retina, tends… Expand
Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice.
- F. Ishizuka, M. Shimazawa, +4 authors H. Hara
- Chemistry, Medicine
- European journal of pharmacology
- 5 March 2013
Crocetin, an aglycone of crocin, is found both in the saffron crocus (Crocus starus L.) and in gardenia fruit (Gardenia jasminoides Ellis). We evaluated the protective effects of crocetin against the… Expand
Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
- Shinsuke Nakamura, Yuichi Chikaraishi, K. Tsuruma, M. Shimazawa, H. Hara
- Chemistry, Medicine
- Experimental eye research
- 2010
Ruboxistaurin, a protein kinase C (PKC) beta inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial… Expand
Mild Endoplasmic Reticulum Stress Promotes Retinal Neovascularization via Induction of BiP/GRP78
- Shinsuke Nakamura, Haruka Takizawa, +4 authors H. Hara
- Biology, Medicine
- PloS one
- 27 March 2013
Endoplasmic reticulum (ER) stress occurs as a result of accumulation of unfolded or misfolded proteins in the ER and is involved in the mechanisms of various diseases, such as cancer and… Expand
Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage
- T. Imai, Sena Iwata, +4 authors H. Hara
- Chemistry, Medicine
- Scientific Reports
- 17 April 2019
After intracranial hemorrhage (ICH), iron is released from the hematoma and induces secondary brain injury. However, the detail effect of iron on blood-brain barrier (BBB) function is still unknown.… Expand
Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression.
- Shinsuke Nakamura, K. Tsuruma, M. Shimazawa, H. Hara
- Medicine
- European journal of pharmacology
- 15 June 2012
Several studies have examined the anti-angiogenic effects of angiotensin II type 1 (AT(1)) receptor antagonists; however, the mechanisms underlying these effects are currently unclear. In the present… Expand
Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma.
- S. Inagaki, K. Kawase, +14 authors H. Hara
- Chemistry, Medicine
- Investigative ophthalmology & visual science
- 10 November 2020
Purpose
To determine a chemical agent that can reduce the aggregation of optineurin (OPTN) in cells differentiated from induced pluripotent stem cells obtained from a patient with normal-tension… Expand
Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina.
- Shunsuke Imai, Y. Inokuchi, Shinsuke Nakamura, K. Tsuruma, M. Shimazawa, H. Hara
- Biology, Medicine
- European journal of pharmacology
- 10 September 2010
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, is used for the clinical treatment of acute cerebral infarction. In this study, we investigated the protective effects of… Expand
Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase
Abstract The aim of this study was to determine the reasons why the intravitreal level of extracellular-superoxide dismutase (EC-SOD) increases in proliferative diabetic retinopathy patients by the… Expand
Control of an object with parallel surfaces by a pair of finger robots without object sensing
- R. Ozawa, S. Arimoto, Shinsuke Nakamura, Ji-Hun Bae
- Engineering, Computer Science
- IEEE Transactions on Robotics
- 1 October 2005
TLDR