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—Asynchronous cellular arrays have gained attention as promising architectures for nanocomputers, because of their lack of a clock, which facilitates low power designs, and their regular structure, which potentially allows manufacturing techniques based on molecular self-organization. With the increase in integration density comes a decrease in the(More)
To elucidate the mechanism of phototoxicity induced as a side effect by some of the new quinolone antibiotics, we studied sparfloxacin (SPFX), lomefloxacin, enoxacin, ofloxacin, and ciprofloxacin. We first examined the photosensitized formation of reactive oxygen species such as singlet oxygen (1O2) and superoxide anion (O2-) mediated by the new quinolones.(More)
To investigate O2- generation in in situ lungs of rats treated with drugs to induce experimental acute respiratory distress syndrome, phorbol myristate acetate (PMA) or endotoxin were injected into rats, who had been continuously infused with 2(methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo[1,2-alpha]pyraz in-3-one (MCLA) and the chemiluminescence in in situ(More)
Although singlet oxygen has been postulated to be a highly reactive and toxic intermediate, there has been no evidence of considerable generation of singlet oxygen in vivo level except for special cases. In this work, we firstly measured the near-infrared emission spectra corresponding to the O2(1 delta g) --> O2(3 epsilon g-) transition of singlet oxygen(More)
Opinions differ widely as to the type of architecture most suitable for achieving the tremendous performance gains expected with computers built by nanotechnology. In this context little research effort has gone into asynchronous cellular arrays, an architecture that is promising for nanocomputers due to (1) its regular structure of locally interconnected(More)
The rate constants for [1O2] [MCLA] and [1O2] [NaN3] were measured by quenching the near-infrared emission (1 delta g----3 sigma g) in steady state with MCLA and NaN3, respectively. 1O2 was constantly generated by energy transfer to O2 from Ar laser-excited Rose Bengal. The Stern-Volmer plots yielded the second-order rate constants of 2.94 x 10(9) M-1 S-1(More)
Asynchronous cellular automata (ACA) are cellular automata that allow cells to update their states independently at random times. Because of the unpredictability of the order of update, computing on ACA is usually done by simulating a timing mechanism to force all cells into synchronicity after which well-established synchronous methods of computation can(More)
Reversible computation has attracted much attention over the years, not only for its promise for computers with radically reduced power consumption, but also for its importance for Quantum Computing. Though studied extensively in a great variety of synchronous computation models, it is virtually unexplored in an asynchronous framework. Particularly suitable(More)
The selective assembly of carboxyphenyl substituted porphyrins on the Au (111) surface has been studied using scanning tunneling microscopy. We find that conformational isomers of the porphyrins are induced upon adsorption and are selectively assembled into hydrogen-bonded supramolecular clusters or wires on the surface. The conformation selective assembly(More)