Shinpei Matsunami

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The relationship between the rate of protein synthesis and the level of messenger RNA (mRNA) in the breast muscle (pectoralis major) was studied to examine the mechanisms regulating muscle protein synthesis in chicks under various nutritional conditions. The fractional synthesis rate (FSR) of protein was measured by a large-dose injection of(More)
The effects of rhG-CSF on T-2-induced leukopenia and lethal toxicity in mice were investigated. First, T-2 was administered by gavage to adult male mice at a dose of 3 mg/kg b.w. daily for 7 days, and rhG-CSF was given i.p. in daily dose of 10 or 30 micrograms/kg b.w./day, beginning on the 2nd day, for 5 days. The peripheral WBC of mice receiving T-2 alone(More)
Methyl paraben (MP) is often used as a preservative in foods, drugs, and cosmetics because of its high reliability in safety based on the rapid excretion and nonaccumulation following administration. Light irradiation sometimes produces unexpected activity from chemicals such as MP; furthermore, there is ample opportunity for MP to be exposed to sunlight.(More)
Recent advances in the treatment of multiple myeloma (MM) using newly developed drugs, such as thalidomide, lenalidomide and bortezomib, have improved the survival of the patients with refractory disease. However, it remains difficult to treat certain populations of MM patients; these patients are considered highrisk cases. Tumor cells obtained from these(More)
The rate of liver protein synthesis in vivo and hepatic messenger ribonucleic acid (mRNA) levels were measured to examine the mechanisms regulating liver protein synthesis in chicks under various nutritional conditions. Fractional synthesis rate (FSR) of liver protein was measured by using a large dose injection of L-[4-3H]phenylalanine. Poly(A)+RNA was(More)
1. The effect of 3-days fasting and the subsequent 3-days refeeding on total messenger ribonucleic acid (mRNA) content in the liver of chicks was investigated. 2. Body weight and liver weight were decreased by fasting, and were increased by refeeding to higher than initial values. 3. There was no influence of fasting and refeeding on RNA and mRNA contents(More)
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