Shinji Yagi

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Accumulating evidence shows that inhibition of the vascular renin-angiotensin system results in suppression of injury-elicited neointima formation. We attempted to determine whether or not combined treatment with an angiotensin II type 1 receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI) has an additive inhibitory effect on(More)
To clarify the effect of cilnidipine, a long-acting dihydropyridine Ca-antagonist that blocks both L- and N-type Ca(2+)-channels, on insulin sensitivity, cilnidipine at 5 to 10 mg/day was administered to ten patients with essential hypertension for 12 weeks. Mean age and body mass index (BMI) were 57.7 +/- 5.0 (SEM) years old and 27.1 +/- 1.5, respectively.(More)
Erectile dysfunction (ED) with aging and diabetes mellitus is caused by impairment of the relaxation evoked by nitric oxide (NO) of penile cavernous smooth muscles and arterioles. However, the mechanism of ED in hypertension is unknown. Carbon monoxide (CO), which is produced by heme oxygenase (HO)-2 in the neuronal system is a neurotransmitter and a(More)
To investigate the effects of the diuretic, indapamide, on blood pressure (BP) and metabolic parameters, thirty hypertensive patients were treated with 1 mg of indapamide either every day or every other day. BP, fasting plasma glucose, lipids, serum potassium and uric acid were determined at baseline and after 3 months of a stable regimen of the drug. At(More)
The p53 tumor suppressor gene may act as an inhibitor of vascular neointima formation in response to injury and in the present study the effects of p53 deficiency on external vascular cuff-induced neointima formation were evaluated. Vascular neointima formation was induced by an external vascular cuff; a polyethylene tube placed around a 2 mm segment of the(More)
To explore the effects of various antihypertensive regimes on microalbuminuria, an angiotensin II receptor blocker (ARB), valsartan, was substituted for or added to treatment with a calcium channel blocker (CCB). After a 6-month CCB baseline period, 28 Japanese hypertensive patients with incipient diabetic nephropathy (defined as a urinary albumin excretion(More)
There is no known treatment for erectile dysfunction (ED) in hypertensive patients. We tested whether or not antioxidative therapy improves ED in the setting of hypertension. Spontaneously hypertensive rats (SHRs) were treated with a control chow or an alpha-tocopherol-enriched chow (12 or 24 mg/100 g chow) for 8 weeks. The isometric tension of corpus(More)
Five Japanese women with regular menstrual cycles (control group) and 5 sulpiride-induced hyperprolactinemic women (sulpiride group) were given a 100-microgram synthetic luteinizing hormone releasing factor (LRF) intravenously, on the 20th day of the menstrual cycle and on the 10th day of the next cycle. The mean responses of luteinizing hormone and(More)
Cytogenetic studies were performed in 35 cases of complete hydatidiform mole, and the results were correlated with maternal age and other clinical parameters. The rate of occurrence of aneuploid cells in the 18- to 39-year age group was 19% of the total cells; the rate in the 43- to 52-year age group was 25%. The rate of aneuploid cells between 2n and 3n(More)
The effect of exogenous estrogen on gonadotropin secretion was studied in postmenopausal women. Twelve postmenopausal Japanese women were administered 40 micrograms/day of ethinyl estradiol (EE) orally throughout the study. The ages of the volunteers ranged between 51 and 86 years. In the fourth week of the study, a daily dose of 200 micrograms of EE was(More)