Shinji Sugimoto

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Changes in blood-brain (BBB) permeability and local cerebral blood flow after intracarotid administration of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) were examined quantitatively in rats with double-tracer autoradiography using [14C]alpha-amino-isobutyric acid and [18F]fluoroantipyrine. Forty-eight female Wistar rats were divided into four groups. The(More)
PURPOSE To study a case of rhabdomyoma of the orbit in a 16-month-old boy. METHOD The child had progressive right proptosis for 1 month. He underwent a computed tomographic scan, which showed an irregular right retrobulbar mass and partial resection. RESULTS Histologic examination disclosed well-differentiated striated muscle cells with a mixture of(More)
The present study was designed to find the reliable parameter(s) for the detection of early neurotoxicity following intracarotid (IC) administration of cisplatin. IC administration was performed for 60 minutes in female Wistar rats derived into four groups according to the dose given (1 mg, 1.2 mg, and 1.5 mg of cisplatin, and normal saline in control(More)
An attempt was made to elucidate the association between retinopathy of prematurity (ROP) and neurological disorders in infants of very low birth weight. In this retrospective study, 1081 Japanese children weighing less than 1500 g at birth were classified into four subgroups according to birth weight. In each subgroup, the association among cerebral palsy(More)
Blood flow was measured in transplanted rat gliomas before and during a constant intravenous infusion of angiotensin II using hydrogen clearance methods. The brain tumor models were produced in syngeneic Wister-King-Aptekman male rats with stereotaxic inoculation of ethylnitrosourea-induced glioma cells (KEG-1). Induced hypertension up to 150 mmHg (mean(More)
ICR-derived retinal dysfunction (IRD) 1 and IRD2 mice are new spontaneous mouse models of rod-cone and rod dysfunctions, respectively. In this study, we investigated the cause of rod dysfunction in IRD1 and IRD2 mice. Gene expression of rod phototransduction proteins was analyzed by quantitative real-time RT-PCR. mRNA levels of Gnat1, which encodes the(More)
An experimental study and mathematical analysis of the corneal reflex test was undertaken in spectacle wearers. In the experimental study, photographs were taken of the corneal reflex through spectacles and the conversion ratios determined as measured in degrees/mm. In the mathematical analysis, the magnification effect of the lens was elucidated by three(More)
Intramedullary spinal cord metastasis was thought to be rare, but the advent of MR imaging and treatment for malignancy have revealed that it is more frequent than we previously thought. We report two cases of intramedullary spinal cord metastasis from lung and rectal colon carcinoma. Their symptoms were aggravated rapidly. We performed surgical treatment(More)
The limited-memory BFGS (L-BFGS) algorithm is a popular method of solving large-scale unconstrained minimization problems. Since LBFGS conducts a line search with the Wolfe condition, it may require many function evaluations for ill-posed problems. To overcome this difficulty, we propose a method that combines L-BFGS with the regularized Newton method. The(More)
This study was conducted to evaluate the positive effect of flotation REST on the production of random sequences, employing both behavioral and physiological measures. The subjects were 7 student volunteers who spent a 40-min. session lying alone on a bed in an isolation box and two 40-min. sessions floating in a commercially produced tank. Polygraph(More)