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- Publications
- Influence
Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.
- Elliott J. Hagedorn, Hanako Yashiro, Joshua W. Ziel, Shinji Ihara, Zheng Wang, D. Sherwood
- Biology, Medicine
- Developmental cell
- 18 August 2009
Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediating… Expand
Basement Membrane Sliding and Targeted Adhesion Remodels Tissue Boundaries During Uterine-vulval Attachment in C. elegans
- Shinji Ihara, Elliott J. Hagedorn, +4 authors David R Sherwood
- Biology, Medicine
- Nature Cell Biology
- 10 March 2011
Large gaps in basement membrane occur at sites of cell invasion and tissue remodelling in development and cancer. Though never followed directly in vivo, basement membrane dissolution or reduced… Expand
In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.
- Benjamin Lacroix, K. G. Bourdages, +4 authors A. Maddox
- Biology, Medicine
- Developmental cell
- 28 April 2014
Microtubules (MTs) are cytoskeletal polymers that undergo dynamic instability, the stochastic transition between growth and shrinkage phases. MT dynamics are required for diverse cellular processes… Expand
SPARC promotes cell invasion in vivo by decreasing type IV collagen levels in the basement membrane
- M. Morrissey, Ranjay Jayadev, +4 authors David R Sherwood
- Chemistry, Biology
- 19 January 2016
Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellular… Expand
SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane
- M. Morrissey, Ranjay Jayadev, +4 authors David R Sherwood
- Biology, Medicine
- PLoS genetics
- 1 February 2016
Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellular… Expand
A secreted type of β1,6 N‐acetylglucosaminyltransferase V (GnT‐V), a novel angiogenesis inducer, is regulated by γ‐secretase
- S. Nakahara, T. Saito, +12 authors E. Miyoshi
- Biology
- 1 December 2006
Glycosyltransferases are present in the Golgi apparatus in a membrane‐bound form and are released from cells after cleavage by certain proteases. β1,6‐N‐Acetylglucosaminyltransferase V (GnT‐V), which… Expand