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Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.
Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediatingExpand
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Basement Membrane Sliding and Targeted Adhesion Remodels Tissue Boundaries During Uterine-vulval Attachment in C. elegans
Large gaps in basement membrane occur at sites of cell invasion and tissue remodelling in development and cancer. Though never followed directly in vivo, basement membrane dissolution or reducedExpand
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In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.
Microtubules (MTs) are cytoskeletal polymers that undergo dynamic instability, the stochastic transition between growth and shrinkage phases. MT dynamics are required for diverse cellular processesExpand
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SPARC promotes cell invasion in vivo by decreasing type IV collagen levels in the basement membrane
Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellularExpand
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SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane
Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellularExpand
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A secreted type of β1,6 N‐acetylglucosaminyltransferase V (GnT‐V), a novel angiogenesis inducer, is regulated by γ‐secretase
Glycosyltransferases are present in the Golgi apparatus in a membrane‐bound form and are released from cells after cleavage by certain proteases. β1,6‐N‐Acetylglucosaminyltransferase V (GnT‐V), whichExpand
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