Shinji Hashimura

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In the isolated frog muscle, the proteinaceous venom extracted from jellyfish (genus Aurelia) produced 1) a complete and irreversible block of indirectly and directly elicited muscle twitch and 2) an irreversible depolarization of the muscle membrane. This venom-induced depolarization was effectively reversed or prevented by the substitution of choline for(More)
The authors extracted a dialyzable substance from sea urchin (Diadematidae) collected in Fiji, and investigated its effect on the frequency of miniature endplate potentials (MEPPs) in the sartorius muscle of the frog. This substance was shown to be different from previously known biologically active substances in many respects. The increase of MEPP(More)
Intrinsic beating activity in the identified molluscan neuron Be-1 can be inhibited for a relatively long time by a short application of histamine. Cyclic AMP enhanced both the amplitude and duration of this inhibitory histamine response (H2-response), while cyclic GMP depressed the H2-response. However, when only these nucleotides were applied, they(More)
In the 4-aminopyridine (4AP) Ringer in which the concentration of 4AP is above 0.005 mM, the frog muscle contracted repetitively by rapid cooling. This contraction was named AP-RCC. It took more than 20 min for 4AP to show the fall effect on the AP-RCC. During the AP-RCC action potentials of the muscle membrane which synchronized with the repetitive(More)
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