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Bone marrow (stem/progenitor) cells have been shown to "differentiate" into cells in multiple tissues, including lung. A low number of hematopoietic stem/progenitor cells also circulate in peripheral blood. The physiologic roles of these cells are still uncertain. This study was designed to test, using parabiotic mice that were joined surgically, whether(More)
We propose a real-time gaze estimation method based on facial-feature tracking using a single video camera that does not require any special user action for calibration. Many gaze estimation methods have been already proposed; however, most conventional gaze tracking algorithms can only be applied to experimental environments due to their complex(More)
Whether DNA damage caused by cigarette smoke leads to repair or apoptosis has not been fully elucidated. The current study demonstrates that cigarette smoke induces single-strand DNA damage in human bronchial epithelial cells. Cigarette smoke also stimulated caspase 3 precursors as well as intact poly (ADP-ribose) polymerase (PARP) production, but did not(More)
Cigarette smoke contains thousands of chemicals, many of which may contribute to cytotoxicity and carcinogenesis. Using assays detecting DNA strand breaks (terminal transferase dUTP nick end labeling [TUNEL]) and DNA content (flow cytometry), we evaluated the genotoxic effect of cigarette smoke extract (CSE) on human fetal lung fibroblasts (HFL-1) cultured(More)
OBJECTIVE The prognosis of idiopathic pulmonary fibrosis (IPF) patients with acute exacerbation (AE) is reported to be extremely poor. Several clinical studies suggest that direct hemoperfusion with polymyxin B-immobilized fiber (PMX) may have beneficial effects on AE in patients with interstitial pneumonia (IP). The aim of this multicenter retrospective(More)
An 82-year old man was admitted to our hospital for evaluation of progressive general malaise. He had previously been in good health. His chest roentgenogram showed reticular shadows and we suspected interstitial lung disease. On admission, his roentgenographic images showed deterioration compared with previous images. Acute lung injury was diagnosed by(More)
TGF-beta signals through TGF-beta receptors and Smad proteins. TGF-beta also augments fibroblast-mediated collagen gel contraction, an in vitro model of connective tissue remodeling. To investigate the importance of Smad2 or Smad3 in this augmentation process, embryo-derived fibroblasts from mice lacking expression of Smad2 or Smad3 genes were cast into(More)
Reminiscence therapy, which is effective for increasing the selfesteem of and for reducing behavioral disturbances in individuals with dementia, is usually conducted in a group led by experienced staff. However, due to the shortage of care attendants, only a limited number of patients at home can receive the benefits of this therapy. To provide this therapy(More)
In this paper, we present preliminary work we have done on designing the TactaPack, a wearable sensor/actuator device that uses a Bluetooth wireless connection to return sensor data to a host, and to receive commands to initiate expressive vibrotactile stimuli. We present our work in the context of a physical therapy application designed to provide more(More)