Shinichirou Taniguchi

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OBJECTIVE To characterize the effect of focal compression by threshold tracking and other excitability measures of human median motor axons. METHODS We conducted a sequence of excitability studies using a software written in BASIC (QTRAC version 4.0, (c)Institute of Neurology, London, UK, with multiple excitability protocol TRONDXM 2) in 24 healthy(More)
The present study investigated neural correlates of affect processing in allodynia patients (n=8) and healthy controls (n=12) with the aid of virtual tactile stimulation. Whole brain functional magnetic resonance imaging was performed for allodynia patients and healthy volunteers while they were shown a video demonstrating light stimulation of the palm and(More)
Psychological factors are known to play an extremely important role in the maintenance and development of chronic pain conditions. However, it is unclear how such factors relate to the central neural processing of nociceptive transmission in healthy individuals. To investigate this issue, the activation of the brain was studied in 30 healthy volunteers(More)
Contralateral thalamus, the place of termination of spinothalamic tract, is affected in patients with pain. We employed single photon emission computed tomography (SPECT) to evaluate the thalamic perfusion in patients with spontaneous neuropathic pain. Ten patients with complex regional pain syndrome (CRPS) and eleven radiculopathiy patients were enrolled(More)
Gene targeting studies in mice have shown that the lack of Ikaros activity leads to T-cell hyperproliferation and T-cell neoplasia, establishing the Ikaros gene as a tumor suppressor gene in mice. This prompted us to investigate whether mutations in Ikaros play a role in human hematological malignancies. Reverse transcription-PCR was used to determine the(More)
In the management of clinical low back pain (LBP), actual damage to lower back areas such as muscles, intervertebral discs etc. are normally targeted for therapy. However, LBP may involve not only sensory pain, but also underlying affective pain which may also play an important role overall in painful events. Therefore we hypothesized that visualization of(More)
OBJECTIVE To test if simple motor imagery, like thumb abduction, preferentially influences the excitability of the spinal or cortical motoneurons. METHODS Ten healthy subjects underwent two separate experiments, each consisting of recording F waves and MEPs from abductor pollicis brevis (APB) in three consecutive sessions: (1) baseline, (2) after(More)
To test the hypothesis that the anterior horn cells become hypoexcitable in the absence of central drive, we recorded F waves simultaneously from the first dorsal interosseous (FDI) and the abductor digiti minimi (ADM) before and after volitionally inactivating one muscle (target) while periodically contracting the other muscle (control). In 14 healthy(More)
We conducted a sequential study of quantitative sensory testing (QST) during compression-induced conduction block of the median nerve to determine relative vulnerability of the small and large myelinated nerve fibers. We tested cold (CPT) and vibratory perception thresholds (VPT) of the third digit in 15 healthy subjects during constant, localized(More)
OBJECTIVE To test if motor imagery prevents the rest-induced suppression of anterior horn cell excitability. METHODS Ten healthy subjects underwent two separate experiments, each consisting of stimulating the median nerve 100 times and recording F-waves from abductor pollicis brevis (APB) in three consecutive sessions: (1) after muscle exercise to(More)