Shingo Okuno

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The BCR-ABL1 fusion gene is the molecular marker of chronic myeloid leukemia (CML). The e19a2 transcript is a rare variant associated with various clinical presentations and courses of CML. We herein present a case of e19a2-positive CML who was intolerant to initial treatment with imatinib and successfully responded to subsequent nilotinib therapy. She(More)
TP53 mutation is associated with various hematological malignancies and immunohistochemistry of p53 has been used as a simple method to establish the presence of a TP53 mutation. Since the significance of p53 expression is controversial in myelodysplastic syndrome (MDS) patients treated with azacitidine (Aza), we analyzed the prevalence of p53 expression as(More)
Regenerating islet-derived protein 3 alpha (REG3A) is a biomarker of lower gastrointestinal graft-versus-host disease (GVHD); however, the biological role of REG3A in the pathophysiology of GVHD is not understood. Here, we examined the association between a single nucleotide polymorphism in the REG3A gene, rs7588571, which is located upstream and within 2(More)
Since the introduction of imatinib, tyrosine kinase inhibitors (TKIs) have become key drugs for treating chronicmyeloid leukemia (CML). Although TKIs used for CML were specifically designed to inhibit Abelson murine leukemia viral oncogene homolog 1 (ABL) kinase, they have had some off-target effects. It is important to recognize and manage adverse events(More)
This paper proposes an implementation of a parallel graph mining algorithm using a task-parallel language having exception handling features. The performance of a straightforward task-parallel implementation is poor for many practical backtrack search algorithms due to pruning employed in them, a worker may prune a useless subtree, which is pruned before(More)
Peripheral blood stem cell apheresis from a healthy donor is indispensable for allogeneic peripheral blood stem cell transplantation. Here, we report a rare adverse event following peripheral blood stem cell apheresis. A female sibling donor, aged 61 years with an unremarkable medical history, complained of pain in the left neck and shoulder and numbness in(More)
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