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Dronedarone is a derivative of amiodarone--a popular antiarrhythmic drug. It was developed to overcome the limiting iodine-associated toxicities of amiodarone. Debutyldronedarone is a major circulating active metabolite of dronedarone in humans. To investigate the pharmacokinetics of dronedarone, a rapid, simple, and sensitive liquid chromatography-tandem(More)
In the retail industry, stockouts have a significant effect on a firm's profitability. When a stockout takes place, retailers often apply one of two strategies to resolve the issue – placing an emergency order with their supplier or arranging a lateral transshipment with a nearby partner store. Choosing the optimal response to a stockout is complicated by(More)
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