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Hemodynamic shear stress via ROS modulates PCSK9 expression in human vascular endothelial and smooth muscle cells and along the mouse aorta.
TLDR
Evidence is provided that low shear stress enhances PCSK9 expression in concert with ROS generation in vascular ECs and SMCs, and it is proposed thatPCSK9-ROS interaction may be important in the development of atherosclerosis in arterial channels with lowShear stress.
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Are Rab proteins the link between Golgi organization and membrane trafficking?
TLDR
Speculation on the essential role of Rab proteins in Golgi organization and protein transport is speculated based on evidence from both yeast and mammalian cells.
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Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis
TLDR
The role of ox-LDL and scavenger receptors in the formation of atheroma is summarized with emphasis on effects of LOX-1 blockade.
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Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis
TLDR
It appears that oxidative stress-mediated damaged mtDNA that escapes autophagy induces a potent inflammatory response in atherosclerosis.
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Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7 g.
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PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy
TLDR
PCSK9 is up-regulated in the ischaemic hearts and determines development of infarct size, cardiac function, and autophagy.
View on Wolters Kluwer
Cross-talk between LOX-1 and PCSK9 in vascular tissues.
TLDR
It is observed that mitochondrial reactive oxygen species (mtROS) plays an initiating role in the LOX-1/PCSK9 interaction, since mtROS induction enhanced and its inhibition reduced the expression of both PCSK9 and LOx-1.
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PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages
TLDR
Elevated levels of PCSK9 potently stimulate the expression of scavenger receptors (SRs) and oxidized liporoptein cholesterol (ox-LDL) uptake in macrophages, and thus contribute to the process of atherogenesis.
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LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis.
TLDR
This study indicates that LOX-1-mediated autophagy and mtDNA damage play an essential role in NLRP3 inflammasome activation in inflammatory disease states.
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Cross-Talk Between PCSK9 and Damaged mtDNA in Vascular Smooth Muscle Cells: Role in Apoptosis.
TLDR
Positive feedback interplay between SMC-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS is suggested, at least in part, bymtROS.
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