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Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles.
TLDR
The docetaxel-loaded AsTNP presents the best anti-glioma effect with improvedglioma bearing survival and could precisely target to the brain glioma, which was a valuable target for gliomas imaging and therapy. Expand
Angiopep-2 and activatable cell-penetrating peptide dual-functionalized nanoparticles for systemic glioma-targeting delivery.
TLDR
A novel drug delivery system was developed forglioma dual targeting and glioma penetrating that effectively targeted gliomas and provided the most favorable antiglioma effect both in vitro and in vivo. Expand
Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization
TLDR
It was shown that the nanoparticels modification with the IL-13 peptide could improve glioma treatment by selectively increasing cellular uptake, facilitating cell internalization, altering the uptake pathway and increasingglioma localization. Expand
Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(ε-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy.
TLDR
Heterogeneous nanoparticles functionalised with GMT8 aptamer-functionalised nanoparticles enhanced tumour penetration and targeted glioblastoma therapy, which is promising for the prognosis of brain gliOBlastoma. Expand
Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment.
TLDR
Treatment with docetaxel-IRNPs displayed best anti-tumor effect with a median survival time of 35 days, which was significantly longer than that of mono-modified and unmodified nanoparticles. Expand
Nanoparticle-Based ARV Drug Combinations for Synergistic Inhibition of Cell-Free and Cell-Cell HIV Transmission.
TLDR
This work shows that physicochemically diverse ARV drugs can be encapsulated within polymeric nanoparticles to deliver multidrug combinations that provide potent HIV chemoprophylaxis in relevant models of cell-free, cell-cell, and mucosal tissue infection and demonstrates that ARV-NP combinations control HIV-1 transmission more efficiently than free-drug combinations. Expand
CORRIGENDUM: Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization
Nanoparticles (NPs) were widely used in drugs/probes delivery for improved disease diagnosis and/or treatment. Targeted delivery to cancer cells is a highly attractive application of NPs. However,Expand
RGD and interleukin-13 peptide functionalized nanoparticles for enhanced glioblastoma cells and neovasculature dual targeting delivery and elevated tumor penetration.
TLDR
In this study, polymeric nanoparticles were functionalized with RGD and interleukin-13 peptide (IRNPs) to construct a neovasculature and tumor cell dual targeting delivery system in which RGD could target αvβ3 on neov as well as IL13Rα2 on GBM cells. Expand
Glioma-homing peptide with a cell-penetrating effect for targeting delivery with enhanced glioma localization, penetration and suppression of glioma growth.
TLDR
The modification of IL-13p selectively enhanced tumor cell uptake, improved the penetration effect of NPs and improved the glioma localization ability, which led to a better tumor-suppression effect. Expand
Behavior and anti-glioma effect of lapatinib-incorporated lipoprotein-like nanoparticles.
TLDR
This study demonstrated the effective uptake ofLTNPs by U87 cells, the passive targeting of LTNPs at tumors and the better antitumor effect of LTnPs. Expand
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