• Publications
  • Influence

Claim Your Author Page
Ensure your research is discoverable on Semantic Scholar. Claiming your author page allows you to personalize the information displayed and manage your publications. Semantic Scholar automatically creates author pages based on data aggregated from public sources and our publisher partners.
  • Mark J Crabtree, Amy L. Tatham, +5 authors Nicholas J. Alp
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2009 (First Publication: 9 January 2009)
  • Tetrahydrobiopterin (BH4) is a critical determinant of endothelial nitric-oxide synthase (eNOS) activity. In the absence of BH4, eNOS becomes “uncoupled” and generates superoxide rather than NO.Expand
  • Jennifer K. Bendall, Nicholas J. Alp, +6 authors Keith M Channon
  • Biology, Medicine, Chemistry
  • Circulation research
  • 2005 (First Publication: 22 September 2005)
  • Endothelial dysfunction in vascular disease states is associated with reduced NO bioactivity and increased superoxide (&OV0151;) production. Some data suggest that an important mechanism underlyingExpand
  • Nicholas J. Alp, Shafi Mussa, +6 authors Keith M Channon
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2003 (First Publication: 1 September 2003)
  • Increased production of reactive oxygen species and loss of endothelial NO bioactivity are key features of vascular disease states such as diabetes mellitus. Tetrahydrobiopterin (BH4) is a requiredExpand
  • Shijie Cai, Nicholas J. Alp, +5 authors Keith M Channon
  • Biology, Medicine
  • Cardiovascular research
  • 2002 (First Publication: 1 September 2002)
  • OBJECTIVES Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) activity. BH4 levels are regulated by de novo biosynthesis; the rate-limiting enzyme is GTPExpand
  • Charalambos Antoniades, Cheerag Shirodaria, +9 authors Keith M Channon
  • Medicine
  • Circulation
  • 2006 (First Publication: 28 August 2006)
  • Background— The circulating form of folic acid, 5-methyltetrahydrofolate (5-MTHF), may have beneficial effects on endothelial function; however, its mechanisms of action remain uncertain. DecreasedExpand
  • Cynthia J. Meininger, Shijie Cai, +6 authors Guoyao Wu
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 2004 (First Publication: 28 September 2004)
  • Nitric oxide (NO) synthesis in endothelial cells is impaired in diabetes. We previously showed that impaired NO synthesis in the spontaneously diabetic BB (BBd) rat is due to decreased levels ofExpand
  • Nick E. J. West, Hongwei Qian, +4 authors Keith M Channon
  • Medicine
  • Circulation
  • 2001 (First Publication: 25 September 2001)
  • Background—Pathological vascular remodeling in venous bypass grafts (VGs) results in smooth muscle cell (SMC) intimal hyperplasia and provides the substrate for progressive atherosclerosis, theExpand