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ETCM: an encyclopaedia of traditional Chinese medicine
ETCM provides predicted target genes ofTCM ingredients, herbs, and formulas, according to the chemical fingerprint similarity between TCM ingredients and known drugs, to facilitate functional and mechanistic studies of TCM.
A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment
This study performed a high-throughput in silico screen and obtained a group of compounds from CDF which possess desirable pharmacodynamical and pharmacological characteristics, and proposed a strategy to develop novel TCM candidates at a network pharmacology level.
A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders
This novel and scientific network pharmacology-based study holistically deciphers that the pharmacological mechanisms of QXHC in the treatment of menstrual disorders may be associated with its involvement into hemopoiesis, analgesia, nutrients absorption and metabolism, mood regulation, as well as immune modulation.
A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma
- Di Chen, Fangbo Zhang, Hongjun Yang
- MedicineEvidence-based complementary and alternative…
- 17 November 2013
The systematic study reveals that the treatment of “FengXieFanFei,” “FeiQiShiXuan” and “QiDaoLuanJi” has effects on the regulation of multiple bioprocesses by herbs containing different ingredients with functions of steroid metabolism regulation, airway inflammation, and ion conduction and transportation.
[Molecular mechanism research on simultaneous therapy of brain and heart based on data mining and network analysis].
- Di Chen, Peng Lu, Fangbo Zhang, Shihuan Tang, Hong-Jun Yang
- BiologyZhongguo Zhong yao za zhi = Zhongguo zhongyao…
The mechanism of the theory of treating heart and brain simultaneously was explained from molecular level by finding out key genes targeted by the components of this formula for both diseases and some particular genes interfered by the component for each disease.
A Systems Biology-Based Approach to Uncovering the Molecular Mechanisms Underlying the Effects of Dragon's Blood Tablet in Colitis, Involving the Integration of Chemical Analysis, ADME Prediction,…
This study integrated chemical analysis, prediction of absorption, distribution, metabolism, and excretion (ADME), and network pharmacology to deepen the understanding of the complex pharmacological mechanisms underlying the effects of dragon's blood tablets in colitis treatment.
BNC Protects H9c2 Cardiomyoblasts from H2O2-Induced Oxidative Injury through ERK1/2 Signaling Pathway
- Fangbo Zhang, Bin Huang, Hongjun Yang
- BiologyEvidence-based complementary and alternative…
- 10 October 2013
The data demonstrated that BNC protects H9c2 cardiomyoblasts from H2O2-induced oxidative injury by increasing antioxidant abilities, activating ERK1/2, and blocking Ca2+-dependent and mitochondria-mediated apoptosis.
A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula
- Jianglong Song, Fangbo Zhang, Hongjun Yang
- ChemistryEvidence-based complementary and alternative…
- 26 November 2013
A computational approach integrating the module detection technique into a 2-class heterogeneous network (2-HN) which models the complex pharmacological system of a TCM formula is proposed, capable of uncovering the mode of action underlying aTCM formula via module analysis.
Research ideas and strategies on the dose-effect relationship of traditional Chinese medicine prescriptions and herbs.
BNC Protects H 9 c 2 Cardiomyoblasts from H 2 O 2-Induced Oxidative Injury through ERK 1 / 2 Signaling Pathway
The potency of BNC for protecting H9c2 cells from oxidative damage is comparable to that of trimetazidine, and preconditioning enhanced antioxidant function by increasing antioxidant abilities, activating ERK1/2, and blocking Ca-dependent and mitochondria-mediated apoptosis.