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Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots
Identification of Echinacoside Metabolites Produced by Human Intestinal Bacteria Using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry.
- Yang-yang Li, Guisheng Zhou, Shihua Xing, P. Tu, Xiaobo Li
- ChemistryJournal of agricultural and food chemistry
- 24 July 2015
An approach combining ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry with MS(E) technology and MetaboLynx software for rapid analysis of the ECH metabolic profile produced by human intestinal bacteria was established and hydroxytyrosol (HT) and 3-hydroxyphenylpropionic acid (3-HPP) were found to be the two bioactive metabolites of ECH.
In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites
Anticomplement and Antimicrobial Activities of Flavonoids from Entada phaseoloides
- Ke-kai Li, Shihua Xing, Meng-yue Wang, Ying Peng, Yuqiong Dong, Xiaobo Li
- BiologyNatural product communications
- 1 July 2012
The antimicrobial results indicated that quercetin, 5,7,4′-trihydroxy-3′-methoxyflavonol and galangin produced the inhibitory activities against MRSA, MSSA, and Standard Enterococcus, while luteolin and rhamnocitrin displayed inhibition against only MRSA and MSSA.
The Gastrointestinal Tract Metabolism and Pharmacological Activities of Grosvenorine, a Major and Characteristic Flavonoid in the Fruits of Siraitia grosvenorii
- Meng-yue Wang, Shihua Xing, T. Luu, Min Fan, Xiaobo Li
- Biology, MedicineChemistry & biodiversity
- 1 November 2015
It is revealed that intestinal bacteria play an important role in the gastrointestinal metabolism of grosvenorine and significantly affect its pharmacological activities.
Effects of Intestinal Microecology on Metabolism and Pharmacokinetics of Oral Wogonoside and Baicalin
- Shihua Xing, Meng-yue Wang, Ying Peng, Xiaobo Li
- Chemistry, BiologyNatural product communications
- 1 April 2017
It is recommended that the root of S. baicalensis should not be co-administered with antibiotics in clinical use and the results suggested that intestinal microbiota may play a key role in the pharmacokinetics and metabolism of peroral baicalin and wogonoside.
Intestinal bacterial metabolism and anti-complement activities of three major components of the seeds of Entada phaseoloides
- Shihua Xing, Meng-yue Wang, Ying Peng, Yuqiong Dong, Xiaobo Li
- BiologyJournal of Natural Medicines
- 1 April 2015
The results indicated that the presence of intestinal bacteria likely plays an important role and that the pharmacological effects of Entadae Semen may be dependent on intestinal bacterial metabolism.
Ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis of In vitro metabolites of lignans from fructus forsythiae by Human Fecal Flora
Background: Phillyrin and (+)-pinoresinol 4-O-β-D-glucoside are the major active furofuran-type lignans in Fructus Forsythiae. The metabolic routes and metabolites of these two lignans are not well…