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Although endothelin-receptor antagonists reduce albuminuria in diabetic nephropathy, fluid retention limits their use. Here, we examined the effect of atrasentan, a selective endothelin A receptor (ET(A)R) antagonist, on albuminuria in a randomized, double-blind, placebo-controlled trial of subjects with diabetic nephropathy already receiving stable doses(More)
BACKGROUND The Problem formulation, Objectives, Alternatives, Consequences, Trade-offs, Uncertainties, Risk attitude, and Linked decisions (PrOACT-URL) framework and multiple criteria decision analysis (MCDA) have been recommended by the European Medicines Agency for structured benefit-risk assessment of medicinal products undergoing regulatory review. (More)
BACKGROUND A semiparametric density ratio method which borrows strength from two or more samples can be applied to moving window of variable size in cluster detection. The method requires neither the prior knowledge of the underlying distribution nor the number of cases before scanning. In this paper, the semiparametric cluster detection procedure is(More)
In this dissertation, a Semiparametric density ratio testing method which borrows strength from two or more samples is applied to moving windows of variable size in cluster detection. This Semiparametric cluster detection method requires neither the prior knowledge of the underlying distribution nor the number of cases before scanning. To take into account(More)
An important goal of research on the cognitive neuroscience of decision-making is to produce a comprehensive model of behavior that flows from perception to action with all of the intermediate steps defined. To understand the mechanisms of perceptual decision-making for an auditory discrimination experiment, we connected a large-scale, neurobiologically(More)
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