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AIM We aimed to determine whether plasma sex hormone levels are associated with activities of daily living (ADL), cognition, depression and vitality in elderly individuals with functional decline. METHODS Two hundred and eight consecutive persons 70 years or older (108 men and 100 women; mean +/- standard deviation, 81 +/- 7 years) with a chronic stable(More)
AIM To assess the age-related change in plasma androgen levels in healthy middle-aged men and whether any clinical parameters are associated with the hormonal change. METHODS The study was comprised of male Japanese office-workers aged 40-64 years, who had undergone an annual health check-up in 2002 and 2007 (96 and 76 men, respectively). Body mass index(More)
Epidemiological studies have shown that low testosterone is associated with metabolic syndrome (MetS) in Caucasian men. We investigated whether testosterone level is related to the prevalence of MetS in middle-aged Japanese men. A cross-sectional survey was conducted in 194 men aged 30–64 years (49±9). Blood sampling was performed in the morning after a(More)
The ability to maintain active and independent living as long as possible is crucial for the healthy longevity. Hormones responsible for some of the manifestations associated with aging are growth hormone, insulin-like growth factor-1 (IGF-1), melatonin, dehydroepiandrosterone (DHEA), sex hormones and thyroid hormones. These hormonal changes are associated(More)
AIM To investigate the relationship between circulating sex hormone levels and subsequent mortality in disabled elderly. METHODS This prospective observational study was comprised of 214 elderly subjects aged 70-96 years (117 men and 97 women; mean ± standard deviation age, 83 ± 7 years), receiving services at long-term care facilities in Nagano, Japan.(More)
Cardiovascular disease is the main contributor of mortality among postmenopausal women. Hormone Replacement Therapy (HRT) has been reported to have a beneficial effect on metabolic and vascular factors. Although, randomized clinical trials have questioned the efficacy of HRT in primary and secondary coronary artery disease (CAD) prevention despite(More)
AIM There is little evidence that dehydroepiandrosterone (DHEA) has beneficial effects on physical and psychological functions in older women. We investigated the effect of DHEA supplementation on cognitive function and ADL in older women with cognitive impairment. METHODS A total of 27 women aged 65-90 years (mean ± standard deviation, 83 ± 6) with mild(More)
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