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BACKGROUND Mass spectrometry (MS) based label-free protein quantitation has mainly focused on analysis of ion peak heights and peptide spectral counts. Most analyses of tandem mass spectrometry (MS/MS) data begin with an enzymatic digestion of a complex protein mixture to generate smaller peptides that can be separated and identified by an MS/MS instrument.(More)
Writing in English might be one of the most difficult tasks for EFL (English as a Foreign Language) learners. This paper presents FLOW, a writing assistance system. It is built based on first-language-oriented input function and context sensitive approach, aiming at providing immediate and appropriate suggestions including translations, paraphrases, and(More)
The in vitro stationary phase proteome of the human pathogen Shigella dysenteriae serotype 1 (SD1) was quantitatively analyzed in Coomassie Blue G250 (CBB)-stained 2D gels. More than four hundred and fifty proteins, of which 271 were associated with distinct gel spots, were identified. In parallel, we employed 2D-LC-MS/MS followed by the label-free(More)
We introduce a new method for learning to detect grammatical errors in learner's writing and provide suggestions. The method involves parsing a reference corpus and inferring grammar patterns in the form of a sequence of content words, function words, and parts-of-speech (e.g., " play ~ role in Ving " and " look forward to Ving "). At run-time, the given(More)
Previous studies have shown that the inhibitory effect of betulinic acid (BA) on specificity protein 1 (Sp1) expression is involved in the prevention of cancer progression, but the mechanism of this effect remains to be delineated. In this study, we determined that BA treatment in HeLa cells increased the sumoylation of Sp1 by inhibiting sentrin-specific(More)
Clinical dogma is that healthy urine is sterile and the presence of bacteria with an inflammatory response is indicative of urinary tract infection (UTI). Asymptomatic bacteriuria (ABU) represents the state in which bacteria are present but the inflammatory response is negligible. Differentiating ABU from UTI is diagnostically challenging, but critical(More)
BACKGROUND Modern biomedical research depends on a complete and accurate proteome. With the widespread adoption of new sequencing technologies, genome sequences are generated at a near exponential rate, diminishing the time and effort that can be invested in genome annotation. The resulting gene set contains numerous errors in even the most basic form of(More)
We introduce a method for learning to translate out-of-vocabulary (OOV) words. The method focuses on combining sublexical/constituent translations of an OOV to generate its translation candidates. In our approach, wildcard searches are formulated based on our OOV analysis, aimed at maximizing the probability of retrieving OOVs’ sublexical translations(More)
Yersinia pestis cells were grown in vitro at 26 and 37 degrees C, the ambient temperatures of its flea vector and its mammalian hosts, respectively, and subjected to subcellular fractionation. Abundance changes at 26 vs 37 degrees C were observed for many outer-membrane (OM) proteins. The cell adhesion protein Ail (y1324) and three putative small(More)
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: Keywords: Elimination strategy Hough transform Line-detection Orientation-histogram(More)