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Aristolochic acids (AA), present in Aristolochia plants, are the toxin responsible for Chinese herbs nephropathy (CHN), a rapidly progressive tubulointerstitial nephritis (TIN). To clarify the mechanisms of the development of CHN, we tried to induce TIN in mice using AA. Three strains of inbred mice, BALB/c, C3H/He and C57BL/6, received 2.5 mg kg(-1) of AA(More)
The concept of batch verifying multiple RSA digital signatures is to find a method that multiple digital signatures can be verified simultaneously in only one exponential operation time. In this article, we proposed a new batch verifying multiple RSA digital signatures scheme. The main contribution of the proposed scheme is that it can easily discover where(More)
OBJECTIVES To survey the knowledge, attitudes, and practices towards safe medication use of first-year college students in Taiwan. METHODS One hundred forty-seven departments in 27 universities were sampled by stratified randomization. Three sections of the questionnaire were developed, including 10 true/false questions to measure knowledge, 4 questions(More)
OBJECTIVE This study examined test-retest agreement and measurement errors for the Rivermead Mobility Index (RMI) and the Mobility subscale of the Stroke Rehabilitation Assessment of Movement (M-STREAM) in patients with chronic stroke and mild to moderate disability. The authors aimed to determine the level of agreement between test and retest as well as(More)
–A novel two-switch high-step-up isolated converter with voltage lift is proposed in this paper. The proposed isolated converter utilizes a transformer with low turn ratio to achieve high step-up gain. The secondary winding charges two boosting capacitors in parallel as switches during the switch-on period, and two boosting capacitors are discharged in(More)
The activity of lipoprotein lipase (LPL), an enzyme responsible for lipoprotein metabolism, would vary in diseases and metabolic disorders. For determination of LPL activity, a highly sensitive high performance liquid chromatography (HPLC) method using a fluorescent reagent, 4-nitro-7-piperazino-2,1,3-benzoxadiazole (NBD-PZ) was applied to determinate the(More)
UNLABELLED The efficacy and safety of maternal tenofovir disoproxil fumarate (TDF) in reducing mother-to-infant hepatitis B virus (HBV) transmissions is not clearly understood. We conducted a prospective, multicenter trial and enrolled 118 hepatitis B surface antigen (HBsAg)- and hepatitis B e antigen-positive pregnant women with HBV DNA ≥7.5 log10 IU/mL.(More)
Aristolochic acids (AAs) which exist in plants of the genus Aristolochia are the toxins responsible for aristolochic acid nephropathy (AAN). To investigate the pharmacokinetics and nephrotoxicity of AAs, rabbits were used in this study. The plasma concentrations of the main components of AAs, aristolochic acid I (AA I) and aristolochic acid II (AA II), were(More)
BACKGROUND Collagen-like surface proteins Scl1 and Scl2 on Streptococcus pyogenes contain contiguous Gly-X-X triplet amino acid motifs, the characteristic structure of human collagen. Although the potential role of Scl1 in adhesion has been studied, the conclusions may be affected by the use of different S. pyogenes strains and their carriages of various(More)