Shih-Chieh Tsai

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Daxx plays a major role in several important signaling pathways including transcription and cell death. It has been postulated that Daxx regulates both events from the nucleus; however, the mechanism by which Daxx is localized in the nucleus remains obscure. Here we show that nuclear localization of Daxx is controlled by two independent signals and importin(More)
An enantioselective esterification process was developed for the synthesis of 2-N-morpholinoethyl (S)-ibuprofen ester prodrug from racemic ibuprofen by using Candida rugosa lipase immobilized on Accurel MP1000 in cyclohexane. Compared with the performance of Lipase MY, the immobilized lipase possesses a higher enzyme activity and thermal stability, but with(More)
We demonstrate a high-power passively Q -switched and mode-locked Nd:YVO(4) laser with a Cr(4+):YAG saturable absorber. 2.7 W of average power with an 18-kHz Q -switched repetition rate was generated at a 12.5-W pump power. The peak power of a single pulse near the maximum of the Q -switched envelope was greater than 100 kW.
We demonstrate a high-power passively mode-locked Nd:YVO (4) laser that uses a saturable Bragg reflector (SBR) with strain relaxation. 23.5 W of average power with ~21.5-ps cw mode-locked pulse trains was generated at a 50-W pump power. Experimental results show that appropriate strain relaxation in the SBR makes the mode-locking operation less sensitive to(More)
Monoclonal antibody complexes have proven very useful in the study of low-density lipoproteins (LDLs). Thus, complexes composed of two different monoclonal antibodies, selected from a panel of 11 different antibodies, and LDL have been employed to map apolipoprotein B (apoB) on the surface of the LDL. In this way, apoB was found to surround the LDL as a(More)
A 159 residue, N-terminal fragment of the human C1s complement component, C1s alpha(159), was expressed in the baculovirus, insect cell system. The protein was abundantly produced 3 days after infection, reaching levels as high as 40 microg/ml in cell culture media. It had a molecular weight of 18,100 (+/-4.9) Da by laser desorption mass spectrometry, close(More)
The ankyrin repeats cofactor-1 (ANCO-1) was recently identified as a novel nuclear receptor corepressor that regulates receptor-mediated transcription through interactions with p160 coactivators and histone deacetylases. Interestingly, exogenously expressed ANCO-1 is localized at distinct subnuclear domains. The relevance of these subnuclear domains and the(More)
We report efficient generation of cw yellow light by use of single-pass sum-frequency mixing from a diode-pumped Nd:YVO(4) dual-wavelength laser with periodically poled lithium niobate. A diode-pumped Nd:YVO(4) dual-wavelength laser is implemented with a three-mirror cavity, and the optimum oscillation condition is obtained from theoretical analysis. We(More)
Simultaneous mode locking and Q switching is accomplished in a diode-pumped Nd:YVO(4)/GaAs laser. The average output power is ~2.0 W at 10.6-W absorbed pump power, and the repetition rate of the Q-switched pulse is ~120 kHz. The mode-locked pulse inside the Q-switched pulse has a repetition rate of ~148 MHz, and its average duration is estimated to be ~100(More)
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