Shigeyoshi Harada

Publications28
h-index13
Citations439
Highly Influential Citations10
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Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds
ABSTRACT N-(4-Chlorophenyl)-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide (NBD-556) is a low-molecular-weight compound that reportedly blocks the interaction between human immunodeficiency virus… Expand
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Human immunodeficiency virus type 1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2.
It has been reported that the addition of a potential N-linked glycosylation site (PNGS) to the gp120 human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein provides protection against… Expand
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Pathways for the emergence of multi-dideoxynucleoside-resistant HIV-1 variants
Objective: To investigate the mechanism by which the Q151M mutation in reverse transcriptase (RT) that confers multi-dideoxynucleoside resistance on HIV-1 and that requires a two base change… Expand
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A minimally cytotoxic CD4 mimic as an HIV entry inhibitor.
Several CD4 mimics have been reported as HIV-1 entry inhibitors which can block the interaction between the viral envelope glycoprotein gp120 and the cell surface protein CD4. We previously found a… Expand
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Identification of Amino Acid Residues Critical for LD78β, a Variant of Human Macrophage Inflammatory Protein-1α, Binding to CCR5 and Inhibition of R5 Human Immunodeficiency Virus Type 1 Replication*
In an attempt to determine which amino acid(s) of LD78β, a variant of human macrophage inflammatory protein-1α, plays a critical role in the interaction with CCR5, we generated six LD78β variants… Expand
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Biphasic CD8+ T-Cell Defense in Simian Immunodeficiency Virus Control by Acute-Phase Passive Neutralizing Antibody Immunization
ABSTRACT Identifying human immunodeficiency virus type 1 (HIV-1) control mechanisms by neutralizing antibodies (NAbs) is critical for anti-HIV-1 strategies. Recent in vivo studies on animals infected… Expand
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Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
Triphosphate 1c is a potent competitive inhibitor of wild-type HIV-1 reverse transcriptase with K(i) close to ddATP. The E-isomer 2c is about 30-times weaker. Triphosphates 1c and 2c interact with… Expand
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CD4 mimics targeting the mechanism of HIV entry.
A structure-activity relationship study was conducted of several CD4 mimicking small molecules which block the interaction between HIV-1 gp120 and CD4. These CD4 mimics induce a conformational change… Expand
  • 53
CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist.
Small molecules behaving as CD4 mimics were previously reported as HIV-1 entry inhibitors that block the gp120-CD4 interaction and induce a conformational change in gp120, exposing its… Expand
  • 38
Small molecular CD4 mimics as HIV entry inhibitors.
Derivatives of CD4 mimics were designed and synthesized to interact with the conserved residues of the Phe43 cavity in gp120 to investigate their anti-HIV activity, cytotoxicity, and CD4 mimicry… Expand
  • 36