Shigetoshi Horiguchi

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2929 The prevalence of IgE-mediated allergic diseases such as asthma, hay fever, and atopic der-matitis has increased dramatically over the past two decades, especially in industrialized countries (1). For example, the incidence of asthma has nearly doubled since 1980 in the United States as well as in Japan (1, 2). However, the precise mechanisms(More)
For two types of motor speech disorder patients, one with amyotrophic lateral sclerosis (ALS), and one with olivo-ponto-cerebellar atrophy (OPCA), two different speech therapy methods, the Silverman method (facilitation of loud phonation) and the intonation emphasis method were used to examine the effectiveness of speech therapy. Acoustic analyses revealed(More)
BACKGROUND Many subjects are sensitized to Japanese cedar pollen but do not develop allergic rhinitis (AR). The aim of this study was to examine the immunologic parameters related to the development of AR in sensitized subjects. METHODS The subjects were 33 adults who were sensitized to Japanese cedar pollen, but had not developed as of 2007. Cedar(More)
Background: Subcutaneous injection route (SCIT) is burdened with the risk of severe adverse events; therefore, sublingual immunotherapy (SLIT) is being increasingly investigated. The efficacy of SLIT in asthma has been reviewed in a Cochrane meta-analysis. Allergic sensitization to Dermatopha-goides pteronyssinus (Dp), Dermatophagoides siboney (Ds) and(More)
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