Shigeto Miura

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BMPRIA is a receptor for bone morphogenetic proteins with high affinity for BMP2 and BMP4. Mouse embryos lacking Bmpr1a fail to gastrulate, complicating studies on the requirements for BMP signaling in germ layer development. Recent work shows that BMP4 produced in extraembryonic tissues initiates gastrulation. Here we use a conditional allele of Bmpr1a to(More)
OX40 expressed on activated T cells is known to be an important costimulatory molecule on T cell activation in vitro. However, the in vivo functional significance of the interaction between OX40 and its ligand, OX40L, is still unclear. To investigate the role of OX40L during in vivo immune responses, we generated OX40L-deficient mice and a blocking(More)
Introduction The incidence of breast cancer has increased greatly in Japan over the past 2 decades [1], and it has been estimated that breast cancer would become the most common malignant disease in Japanese females by the year 2000 [2]. One of the main risk factors for breast cancer in menopausal women is obesity [3,4]. The increased amount of adipose(More)
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