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MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb
TLDR
During chick, mouse and zebrafish limb/fin development, a known MAPK/ERK regulator, Mkp3, is induced in the mesenchyme by fibroblast growth factor 8 (FGF8) signalling, through the PI(3)K/Akt pathway, suggesting that MKP3 has a key role in mediating the proliferative, anti-apoptotic signalling of AER-derived FGF8. Expand
Transcriptional Co-activators CREB-binding Protein and p300 Regulate Chondrocyte-specific Gene Expression via Association with Sox9*
TLDR
It is demonstrated that CBP and p300 function as co-activators of Sox9 for cartilage tissue-specific gene expression and chondrocyte differentiation. Expand
Tissue preferential expression of estrogen receptor gene in the marine snail, Thais clavigera.
TLDR
Investigation of molluscan estrogen receptors from the prosobranch mollusc Thais clavigera suggests importance of tcER1 in the seasonal development of reproductive organs in T. clvigera. Expand
Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9.
Chondrogenesis is a multistep pathway in which multipotential mesenchymal stem cells (MSC) differentiate into chondrocytes. The transcription factor Sox9 (SRY-related high mobility group-Box gene 9)Expand
Stress-induced Translation of ATF5 mRNA Is Regulated by the 5′-Untranslated Region*
TLDR
The results suggest that translation of ATF5 is regulated by the alternative 5′-UTR region of its mRNA, and ATF5 may play a role in protecting cells from amino acid limitation or arsenite-induced oxidative stress. Expand
Regulation of heme oxygenase-1 gene expression through the phosphatidylinositol 3-kinase/PKC-zeta pathway and Sp1.
TLDR
How NGF contributes to protection of target cells against oxidative stress is elucidates and a mechanistic connection between the survival signal elicited by nerve growth factor and the antioxidant cell defence represented by heme oxygenase-1 is reported. Expand
Prolonged hypoxia accelerates the posttranscriptional process of collagen synthesis in cultured fibroblasts.
TLDR
Results suggest that hypoxic enhancement of the posttranscriptional step of collagen synthesis contributed to the accelerated deposition of collagen fibrils. Expand
The 5′‐untranslated region regulates ATF5 mRNA stability via nonsense‐mediated mRNA decay in response to environmental stress
TLDR
The studies show that ATF5 mRNA is a naturally occurring normal mRNA target of nonsense‐mediated decay, and provide evidence for linkage between stress‐regulated translational regulation and the mRNA decay pathway. Expand
N-terminal Hydrophobic Amino Acids of Activating Transcription Factor 5 (ATF5) Protein Confer Interleukin 1β (IL-1β)-induced Stabilization*
TLDR
The results show that the N-terminal hydrophobic amino acids play an important role in the regulation of ATF5 protein expression in IL-1β-mediated immune response and that ATF5 is a negative regulator for IL- 1β-induced expression of SAA1 and SAA2 in HepG2 cells. Expand
Amino acid limitation induces expression of ATF5 mRNA at the post-transcriptional level.
TLDR
Results indicate that amino acid limitation regulates ATF5 mRNA expression during post-transcription in a rapamycin-independent manner, and the potential role for ATF5 in protecting cells from amino acid-limitation is of considerable interest. Expand
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