Shigeo Orii

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The sequencing of complete genomes allows analyses of the interactions between various biological molecules on a genomic scale, which prompted us to simulate the global behaviors of biological phenomena on the molecular level. One of the basic mathematical problems in the simulation is the parameter optimization in the kinetic model for complex dynamics,(More)
In a multicellular organism, a single cell—an egg—or a group of cells develops into a certain pattern with a variety of cell types. The variety of cell types are created through cell differentiation; the differentiation starts from an initial type, and then the initial type changes into several intermediate types before differentiating into the final type.(More)
New derivatization methods using ferrocene reagents have been developed for the determination of steroid glucuronides by high-performance liquid chromatography with electrochemical detection. Condensation of glucuronides with 2-ferrocenylethylamine is effected in the presence of water-soluble carbodiimide and 1-hydroxybenzotriazole. The resulting amides(More)
The sequencing of complete genomes allows analyses of the interactions between various biological molecules on a genomic scale, which prompted us to simulate the global behaviors of biological phenomena on the molecular level. One of the basic mathematical problems in the simulation is the parameter optimization in the kinetic model for complex dynamics,(More)
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