Shigenobu Umeki

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BACKGROUND Heparin-binding epidermal growth factor-like growth factor is an hepatotrophic factor expressed in non-parenchymal liver cells but not in hepatocytes in regenerating rat liver after partial hepatectomy. Human hepatocellular carcinoma cells also produce this growth factor. In this study, the expression of the growth factor in the hepatocytes of(More)
Previously, the guanylate cyclase activity of Tetrahymena pyriformis was shown to be activated by an endogenous modulator (calmodulin)-like protein (Na-gao, S., Suzuki, Y., Watanabe, Y., and Nozawa, Y. (1979) Biochem. Biophys. Res. Commun. 90, 261-268). This protein has now been identified as the modulator protein. The identification was based on the(More)
Epinephrine modulation of the fatty acyl-CoA desaturase activities in Tetrahymena microsomes, namely the stimulation of delta 9 desaturase activity with a decreased activity of delta 12 desaturase, was markedly inhibited by dexamethasone administered 30 min prior to epinephrine addition. This effect by dexamethasone was dose-dependent. With epinephrine or(More)
Preincubation ofTetrahymena pyriformis cells with dexamethasone inhibited the microsomal fatty acyl-CoA desaturase activities of isoproterenol-induced modulation; that is, an increase in Δ9-desaturase activity accompanied by a decrease in Δ12-desaturase activity. Although isoproterenol caused an increase in Δ12-terminal component activity with decreased(More)
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been reported to stimulate DNA synthesis of the hepatocytes in culture and highly express in regenerating rat liver after partial hepatectomy. We examined mitogenic effects and activation of transcription factors caused by exogenous human HB-EGF (hHB-EGF) in mouse liver. The mean(More)
The delta 9-desaturase system in liver microsome from rats treated chronically with ethanol was studied. Stearoyl-CoA desaturase activity decreased by 80% and palmitoyl-CoA desaturase activity was not detectable in microsomes from ethanol-fed rats, while activities of electron transport components such as NADH-cytochrome c and NADH-ferricyanide reductases(More)
A 75-g oral glucose tolerance test (OGTT) was performed on 18 patients with chronic respiratory failure and without fasting hyperglycemia, positive urine glucose, or hepatic/pancreatic disorders. Underlying diseases in these patients were pulmonary emphysema (11 cases, 61%), pulmonary tuberculosis (5 cases, 28%), and chronic bronchial asthma (2 cases, 11%).(More)