Shigeki Ohmori

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BACKGROUND POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes) syndrome, a rare cause of demyelinating neuropathy associated with multiorgan involvement, has been increasingly recognised. Polyneuropathy is often an initial manifestation and therefore the disorder can be misdiagnosed as chronic inflammatory demyelinating(More)
Fasciculations are characteristic features of amyotrophic lateral sclerosis (ALS), suggesting abnormally increased excitability of motor axons. Previous nerve excitability studies have shown reduced axonal potassium currents in ALS patients that may contribute to the hyperexcitability and thereby generation of fasciculations. To clarify changes in axonal(More)
OBJECTIVE The aim of this study was to investigate whether axonal excitability indices are associated with survival in patients with amyotrophic lateral sclerosis (ALS). Previous nerve excitability studies suggested increased persistent sodium currents in motor axons of patients with ALS, which lead to axonal hyperexcitability and potentially enhance(More)
BACKGROUND Whether or not antiganglioside antibodies are related to axonal or demyelinating Guillain-Barré syndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted in Western and Asian countries. OBJECTIVE To clarify whether antiganglioside antibodies are associated with axonal dysfunction in Japanese and Italian GBS(More)
The purpose of the present study was to evaluate the profiles of the bone strength of rats treated from infancy with various drugs. Young female Sprague-Dawley rats were classified into five groups according to the composition of their diets. They underwent resection of their femurs for a three-point flexion test and an impaction test at 6, 8, 12, and 16(More)
An unusual case of intradiploic epidermoid tumor is reported. In this case, a soft mass located over the parietal bone was noted shortly after birth. The mass gradually enlarged. The tumor underwent malignant change after several excisions and repeated inflammations. The patient was successfully treated with extensive excision, radiotherapy, and(More)
The authors described the case of a normotensive 40-year-old female with severe headache and vomiting. Neurological findings on admission to our hospital revealed no deficits, but plain CT findings indicated subarachnoid hemorrhage in the ambient, supracerebellar, quadrigeminal, and right lateral pontine cisterns. Left vertebral angiograms made through a(More)
UNLABELLED It is desirable for neurosurgeons to be able to evaluate cord functions. To assess electrophysiologically functional status of spinal cord, cortical and spinal somatosensory evoked potentials (SEP) were studied in 33 patients with cervical radiculomyelopathy; 11 cases of cervical spondylosis, 11 cases of OPLL, 3 cases of narrow canal, 2 cases of(More)
OBJECTIVE Bortezomib is a proteasome inhibitor with high efficacy for multiple myeloma but with severe peripheral neurotoxicity, leading to dose modification and severe neurological disability. This study aimed to investigate the pathophysiology of bortezomib-induced neuropathy. METHODS Threshold tracking was used to assess the excitability of sensory and(More)
BACKGROUND In amyotrophic lateral sclerosis (ALS), muscle wasting preferentially affects the abductor pollicis brevis (APB) and first dorsal interosseous over the abductor digit minimi (ADM), and this is termed 'split hand'. Previous axonal excitability studies have suggested increased nodal persistent sodium current and reduced potassium current in motor(More)