Shigeji Matsubara

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OBJECTIVES To observe the expression of beta-3-adrenoceptor in the detrusor muscle in female rats and investigate the relaxant effect of beta-adrenoceptor agonists on detrusor muscle in ovariectomized rats with or without estrogen replacement therapy. METHODS We first performed reverse transcriptase-polymerase chain reaction to demonstrate mRNA encoding(More)
Mittels Chromatographie auf Calciumphosphat-DEAE-Cellulose lassen sich aus Hämolysat von Menschenerythrocyten zwei Fraktionen gereinigter Katalase darstellen. Im Gegensatz zu den Fraktionen aus normalen und homozygot akatalatischen Zellen zeigen die aus Blut heterozygoter Defektträger isolierten Katalasefraktionen ein elektrophoretisch verschiedenes(More)
Osteocalcin (OC), a major noncollagenous bone matrix protein, is expressed prevalently in prostate cancer epithelial cells, adjacent fibromuscular stromal cells, and osteoblasts in locally recurrent prostate cancer and prostate cancer bone metastasis [Matsubara, S., Wada, Y., Gardner, T.A., Egawa, M., Park, M.S., Hsieh, C.L., Zhau, H.E., Kao, C., Kamidono,(More)
Changes in genomic and phenotypic expression of progressing prostate tumors and their stroma occur in a dynamic fashion based on bidirectional signaling from stromal-epithelial interactions. These interactions may underlie the ability of prostate cancer cells to survive and proliferate in the prostate and bone. By investigating the phenotypic and genotypic(More)
1. By column chromatography on DEAE-cellulose calcium phosphate mixed gel red cell catalase can be separated in two fractions, 0.15 M saline and 0.15 M secondary phosphate being used as eluants. 2. The fractions obtained from blood of normal subjects and of homozygous acatalasia cases differ in electrophoretic mobility and in heat stability. Of the(More)
There are numerous arguments for the predictive factors of positive prostate biopsies, differing according to race and region. This study aimed to determine predictive factors for a positive prostate biopsy in East Asian, especially Japanese men, using clinical, laboratory, and transrectal ultrasound (TRUS) findings. Data were collected from 466 men who(More)
A 55-year-old man was referred to our department with the chief complaint of left flank pain. Computed tomography and magnetic resonance imaging demonstrated a left hydronephroureter due to the ureteral stenosis with a mass. We considered the possibility of a malignant neoplasm, and performed laparoscopic left total nephroureterectomy. Microscopic(More)
Prostate cancer has a high propensity to metastasize to bone, which often resists hormone, radiation, and chemotherapies. Because of the reciprocal nature of the prostate cancer and bone stroma interaction, we designed a cotargeting strategy using a conditional replication-competent adenovirus to target the growth of tumor cells and their associated(More)
The substantial advances made in recent years in the molecular biology of malignant urological tumors and the associated progressive analysis of these conditions at a molecular level have spurred research aimed at gene-based treatment. In the field of prostate cancer, while there have been many ground-breaking studies particularly in the United States, none(More)
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