Shigehiro Kuroki

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Nitric oxide (NO) inhibits platelet aggregation, proliferation of vascular smooth muscle cells, and leukocyte adhesion to endothelial cells. Thus, genetic variation in or near NO synthase may be involved in the pathogenesis of coronary artery disease (CAD). We investigated the association between CAD and endothelial constitutive NO synthase (ecNOS) and(More)
Peripheral polyneuropathy and the complication of eosinophilic fasciitis (EF) is rare; only 2 such cases have been described previously. A 40-year-old woman suffered from swelling of the extremities after strenuous exercise and complained of bilateral paresthesia on the soles of her feet. The diagnosis was EF according to clinical symptoms, peripheral(More)
OBJECTIVE While much attention is given to the fifth vital sign, the utility of the 4 classic vital signs (blood pressure, respiratory rate, body temperature, and heart rate) has been neglected. The aim of this study was to assess a possible association between vital signs and the Sequential Organ Failure Assessment (SOFA) score in patients with sepsis. (More)
BACKGROUND The aim of this study was to evaluate the clinical usefulness of a semiquantitative procalcitonin kit for assessing severity of sepsis and early determination of mortality in affected patients. METHODS This was a prospective, observational study including 206 septic patients enrolled between June 2008 and August 2009. Disseminated intravascular(More)
A 61-year-old Japanese man with a neoplasm of unknown primary origin without skin lesions was admitted to our department. Computed tomography showed multiple metastatic lesions in the lung, liver, spleen, bilateral adrenal gland, and bone (Picture 1). Moreover, the patient had been suffering from melanuria for 1 month (Picture 2, 3). Cytological urine(More)
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