Shifang Zhao

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Patterning of electrospun nanofibers has recently attracted much attention for its usefulness in a wide range of applications. This paper reports on the generation of spatially defined nanofibrous patterns by direct deposition of electrospun nanofibers onto a variety of insulating substrates. It was found that topographical features of different(More)
Scaffolds play an important role in directing three-dimensional (3-D) cartilage regeneration. Our recent study reported the potential advantages of electrospun gelatin/polycaprolactone (GT/PCL) membranes in regenerating 3-D cartilage. However, it is still unknown whether the changes of GT/PCL ratio have significant influence on 3-D cartilage regeneration.(More)
PURPOSE The purpose of this work was to investigate the effect of a hydroxyapatite (HA) coating doped with zinc (Zn), magnesium (Mg), or strontium (Sr) on implant osseointegration in ovariectomized rats. MATERIALS AND METHODS The HA coating doped with trace elements was produced by electrochemical deposition. Surface properties were tested by field(More)
Novel "micelles enhanced" polyelectrolyte (PE) capsules based on functional templates of hybrid calcium carbonate were fabricated. Evidences suggested that the structure of capsule wall was different from that of conventional PE capsules, and the wall permeability of these PE capsules changed significantly. Lysozyme, a positively charged protein in neutral(More)
OBJECTIVE The objective of this study was to investigate the effect of hydride ion on bone formation and bone-bonding strength at the early stage of implantation. STUDY DESIGN Implants and plates were treated in 2 ways: test implant (implant surface with hydride ion) and control implant (implant surface without hydride ion). Crystal structure of plate(More)
PURPOSE This study established local delivery with a calcium phosphate (CaP) coating and investigated effects of delivery on implant osseointegration by in vitro and in vivo experiments. MATERIAL AND METHODS Simvastatin was prepared onto titanium surfaces with varying concentration (10⁻⁷, 10⁻⁶, 10⁻⁵, and 10⁻⁴ mol/L). Surface characteristics were performed(More)
Surface modification of titanium (Ti) using biomolecules has attracted much attention recently. In this study, a new strategy has been employed to construct a stable and bioactive coating on Ti. To this end, a derivative of hyaluronic acid (HA), i.e. HA-GRGDSPC-(SH), was synthesized. The disulfide-crosslinked Arg-Gly-Asp (RGD)-containing collagen/hyaluronic(More)
PURPOSE The purpose of this study was to investigate bone responses to simvastatin-loaded porous implant surfaces in an ovariectomized model. MATERIALS AND METHODS Roughened implants were divided into a control group (n = 32), test group 1 (n = 32), and test group 2 (n = 32). Test implants were immersed into 10?7 mol/L (test group 1) or 10?6 mol/L (test(More)
PURPOSE The aim of this study was to evaluate the effect of an electrochemically deposited nanohydroxyapatite (EDHA) coating on the bone bonding of sandblasted and dual acid-etched titanium implants. MATERIALS AND METHODS One hundred EDHA-coated and uncoated sandblasted/dual acid-etched implants (3 mm in diameter, 10 mm long) were inserted into the(More)
The deficient osseointegration and implant-associated infections are pivotal issues for the long-term clinical success of endosteal Ti implants, while development of functional surfaces that can simultaneously overcome these problems remains highly challenging. This study aimed to fabricate sophisticated Ti implant surface with both osteogenic inducing(More)