Shi-shu Zhu

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OBJECTIVE To investigate the efficacy and safety of ademetionine for treatment of cholestatic or mixed-type drug-induced liver disease (DILD) in children. METHODS The children with DILD were divided into the treated group and control group. Yinzhihuang Granule was orally administered and Compound Glycyrrhizin Injection intravenously given in patients of(More)
OBJECTIVE To discuss the efficacy of Leucogen tablets treatment lessen the hematological reaction and raise the efficacy therapy of interferon in chronic hepatitis B treated with PEG-alpha interferon and alpha interferon. METHODS A total of 395 patients with HBeAg-positive chronic hepatitis B (CHB) inpatients from January 2002 to February 2011. Group: All(More)
BACKGROUND AND OBJECTIVES The clinical features and efficacies of antivirals for children with hepatitis C virus (HCV) infections that are acquired through different transmission routines are poorly understood worldwide. This study investigated the clinical characteristics of children who were infected via iatrogenic means and analyzed the efficacy of(More)
OBJECTIVE To determine the cellular immunological abnormalities in children with chronic hepatitis C virus infection. METHODS (1) The quantity of the peripheral blood T cell subsets in 16 children with chronic hepatitis C virus infection and 10 healthy blood donors was detected by FACS. (2) The levels of the TH1/TH2 cytokines secretion of PBMC in patients(More)
Clinical data on children with chronic hepatitis C (CHC) remain extremely limited. This study investigated sustained virologic response (SVR) to alfa-interferon 2b plus RBV treatment in children aged 1-6 years with unsafe injection-acquired CHC. 154 children with CHC aged 1 to 6 years were enrolled, 101 of them were male (65.6%) and 53 were female (34.4%),(More)
OBJECTIVE To investigate the relation of HBV genotypes to clincal features in children with chronic hepatitis B. METHODS The genotypes of serum HBV DNA from 404 children with chronic hepatitis B were determined by PCR using type-specific primers. RESULTS For the 404 children, genotype B in 99 (24.5%), genotype C in 285 (70.5%). For the 75 children from(More)
OBJECTIVE To analyze the etiology, clinical and laboratory characteristics of hepatic failure in 105 children. METHODS The clinical data of 105 children with hepatic failure treated in our hospital from January 1986 to June 2003 were retrospectively analyzed by EXCELL 2000 and t test. RESULTS (1)Of the 105 children with hepatic failure, 9 were cases(More)
BACKGROUND To evaluate treatment effectiveness and safety of bicyclo tablets in children with chronic hepatitis B or C. METHODS A randomized controlled trial was conducted in 148 children with chronic hepatitis B or C for evaluating safety, tolerability, and efficacy of treatment with bicyclo tablets or Hugan tablets. Children in therapy group were(More)
BACKGROUND The association of hepatitis B virus (HBV) genotypes/subgenotypes with clinical characteristics is increasingly recognized. However, the virologic and clinical features of HBV genotypes/subgenotypes in pediatric patients remain largely unknown. METHODS Four hundred and eighty-seven pediatric inpatients with CHB were investigated, including 217(More)
OBJECTIVE To analyze the prognostic factors of liver failure in children. METHODS The clinical data of 105 children with liver failure treated in the No. 302 Hospital in the past 17 years were retrospectively analyzed. The related factors were analysed by EXCELL 2000 and STATA 7.0, multivariate statistical analysis was performed by Logistic regression. (More)