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require only a small amount of hand-annotated training, but require this for every relation of interest. This still presents a knowledge engineering bottleneck, when one considers the unbounded number of relations in a diverse corpus such as the web. Shinyama and Sekine (2006) explored unsupervised relation discovery using a clustering algorithm with good(More)
Arsenic trioxide (As2O3) is established as one of the most effective drugs for treatment of patients with acute promyelocytic leukemia, as well as other types of malignant tumors. However, HL-60 cells are resistant to As2O3, and little is known about the underlying resistance mechanism for As2O3 and its biomethylation products, namely, monomethylarsonous(More)
Traditional methods for identifying food-borne pathogens are time-consuming and laborious, so it is necessary to develop innovative methods for the rapid identification of food-borne pathogens. Here, we report the development of silicon-based optical thin-film biosensor chips for sensitive detection of 11 food-borne pathogens. Briefly, aldehyde-labeled(More)
Bupivacaine is one of the most toxic local anesthetics but the mechanisms underlying its neurotoxicity are still unclear. Intracellular nicotinamide adenine dinucleotide (NAD+) depletion has been demonstrated to play an essential role in neuronal injury. In the present study, we investigated whether intracellular NAD+ depletion contributes to(More)
There are kinds of corners in the mould feature, and these corners bring many problems to the mould processing. This paper summarizes the current processing problems of die corner and common processing methods in detail. The latest research results including the cutting tool path and the numerical control technology are discussed to solve the corner(More)
  • Shi Xu
  • 2015
This review discusses the molecular mechanism involved in the targeting and delivery of antibody-drug conjugates (ADCs), the new class of biopharmaceuticals mainly designed for targeted cancer therapy. this review goes over major progress in preclinical and clinical studies of ADCs, in the past 5 years. The pharmacokinetics and pharmacodynamics of ADCs(More)
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