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BACKGROUND Dickkopf-1 (DKK1), a secreted protein, is known as a negative regulator of the Wnt signaling pathway, which has been implicated in the development of several types of cancers. Clinical significance of serum DKK1 in lung cancer remains to be determined. METHODS A novel time-resolved immunofluorometric assay was developed. By use of this method,(More)
Thirty-six wistar rats (150-250 g body weight) were randomly divided into two groups. There were equal numbers of male and female rats in each group. Each group of rats was given either 0.5 ml normal saline or calcitonin gene-related peptide (CGRP, 20 micrograms/kg dissolved in 0.5 ml normal saline) intravenously within 5 min. Coronary arteries of these(More)
OBJECTIVE To compare the effects of letrozole and clomiphene citrate on the expression of HOXA10 and integrin alpha(v)beta(3) in the uterine epithelium in rats. DESIGN Controlled prospective study. SETTING Teaching hospital and university research laboratory. ANIMAL(S) Sixty sexually mature female Wistar-Albino rats that were 20 weeks of age. (More)
Nogo-66 and NgR are important receptors inhibiting neuronal regeneration and therefore are targets for treating CNS injury. Antagonists of this receptor including blocking antibodies are potential therapeutic agents for CNS axonal injuries such as spinal cord and brain trauma. A new antibody (IgG) releasing system has been developed by covalently attaching(More)
In previous studies, lactate dehydrogenase A (LDHA) was identified as one of the leading genes that promote the proliferative and tumorigenic potential of malignancies. However, less definitive evidence was reported in hepatocellular carcinoma (HCC) cells. Furthermore, the role of LDHA in promoting metastasis of HCC, and its possible mechanism, is not(More)
BACKGROUND Immunoradioassay (IRMA) with (125)I-labeled monoclonal antibodies is widely used to measure levels of cancer antigen (CA) 72-4. We investigated a time-resolved immunofluorometric assay (TR-IFMA) to determine its sensitivity and specificity compared with those of IRMA. METHODS We used 2 CA 72-4-specific monoclonal antibodies with different(More)
In acute cerebral ischemia there are severe damages of endothelium recognized as the stimuli for secretion of endothelin-1, that is a endothelium-derived peptide and seems to be the most potent vasoconstrictor known. The goal of this study is to measure plasma endothelin-1 level in patients with cerebral infarction and determine the relationship between(More)
In acute cerebral ischemia there are severe damages of endothelium which have been recognized as the stimuli to secrete endothelin-1, an endothelium-derived peptide and the most potent vasoconstrictor ever known. This study was to measure plasma endothelin-1 level in patients with cerebral infarction and explore the relationship between endothelin-1 and(More)
Essential fatty acid deficiency was initiated in young and mature mice. The metabolism of 20∶3(n−9) and 22∶3(n−9) in brain subcellular fractions was followed after the mice were switched from the deficient diet to a corn oil supplemented diet. After switching to the supplemented diet, the proportions of (n−9) polyunsaturated fatty acids in brain in both(More)
BACKGROUND Stent thrombosis (ST) is an important end point in cardiovascular clinical trials. Adjudication is traditionally based on clinical event committee (CEC) review of case report forms and source documentation rather than angiograms. However, the degree to which this method of adjudication is concordant with the review of independent angiographic(More)