Sheryl E. Chocron

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This work presents a thorough electrochemical and reliability analysis of a sensing scheme for the antipsychotic clozapine. We have previously demonstrated a novel detection approach for this redox-active drug, highly effective in schizophrenia treatment, based on a catechol-modified chitosan film. The biomaterial film enables amplification of the oxidative(More)
We present the first demonstration of an electrochemically-active biomaterial probe for schizophrenia treatment monitoring, and its integration in lab-on-a-chip devices. The probe consists of the naturally derived polymer, chitosan, grafted with catechol to provide a redox cycling system. These modifications to the probe significantly amplify the(More)
This paper reports on an experimental study of the ability to use ascorbic acid as a reducing agent for a clozapine (CLZ) biosensor based on redox cycling electrochemistry. Ascorbic acid, which is naturally present in the blood serum, was related to the current reducing mediator, hexaammineruthenium(III) (Ru). The performance of these two candidate(More)
Clozapine is the most effective antipsychotic medication for schizophrenia, but it is underutilized because of the inability to effectively monitor its treatment efficacy and side effects. In this work, we demonstrate the first analytical micro-system for real-time monitoring of clozapine serum levels. An electrochemical lab-on-a-chip is developed and(More)
Mental health disorders are complex and poorly understood but would benefi t from real-time chemical analysis capable of assessing a patient’s current status, personalizing a therapeutic action, and monitoring compliance. Here, an electrochemical sensor is reported for detecting the antipsychotic drug clozapine which is one of the most effective but(More)
BACKGROUND Clozapine is the most effective antipsychotic drug for schizophrenia treatment, however it is currently underused. In order to understand the barriers of frequent blood draws for white blood cell counts (WBCs) and clozapine levels, we developed a psychiatrist survey and began and integrative approach of designing a point-of-care device that could(More)
Clozapine (CLZ), a dibenzodiazepine, is demonstrated as the optimal antipsychotic for patients suffering from treatment-resistant schizophrenia. Like many other drugs, understanding the concentration of CLZ in a patient's blood is critical for managing the patients' symptoms, side effects, and overall treatment efficacy. To that end, various electrochemical(More)
When measuring chemical information in biological fluids, challenges of cross-reactivity arise, especially in sensing applications where no biological recognition elements exist. An understanding of the cross-reactions involved in these complex matrices is necessary to guide the design of appropriate sensing systems. This work presents a methodology for(More)
Title of Document: INTERFERENCE STUDIES USING MULTIDIMENSIONAL MAPPING OF CROSS-REACTIVE SENSORS: APPLICATIONS IN BLOOD MONITORING OF CLOZAPINE Sheryl E. Chocron, Master of Science, 2014 Directed By: Reza Ghodssi, Herbert Rabin Distinguished Chair of Engineering, Electrical and Computer Engineering Point-of-care sensors are used in clinical applications for(More)
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