Sherry B. Schueler

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Previous investigations have demonstrated that adrenal chromaffin cells survive poorly when grafted into the striatum of rodents, nonhuman primates, and patients with Parkinson's disease. This poor survival has been attributed to the low levels of endogenous NGF within the striatum. However, chromaffin cells isolated from the nonchromaffin constituents of(More)
The initial rationale for using adrenal chro-maffin cells in transplantation experiments was to provide a paraneural source of dopamine to replenish the dopamine insufficiency created in animal models of parkinsonism and idiopathic Parkinson's disease. Intraventricular transplants of adrenal medulla (AM) survive, synthesize and secrete eatecholamines, and(More)
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