Sherry B. Schueler

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Previous investigations have demonstrated that adrenal chromaffin cells survive poorly when grafted into the striatum of rodents, nonhuman primates, and patients with Parkinson's disease. This poor survival has been attributed to the low levels of endogenous NGF within the striatum. However, chromaffin cells isolated from the nonchromaffin constituents of(More)
The GTP-driven component of Ca(2+) uptake in red beet (Beta vulgaris L.) plasma membrane vesicles was further characterized to confirm its association with the plasma membrane Ca(2+)-translocating ATPase and assess its utility as a probe for this transport system. Uptake of (45)Ca(2+) in the presence of GTP demonstrated similar properties to those(More)
Adrenal medullary grafts generally exhibit poor viability when grafted into the striatum. Previous work in our laboratory demonstrated that chromaffin cells can survive well for up to 2 mo following grafting into the intact rat striatum after cells are isolated from the nonchromaffin supporting cells (fibroblasts and endothelial cells) of the adrenal(More)
The initial rationale for using adrenal chromaffin cells in transplantation experiments was to provide a paraneural source of dopamine to replenish the dopamine insufficiency created in animal models of parkinsonism and idiopathic Parkinson’s disease. Intraventricular transplants of adrenal medulla (AM) survive, synthesize and secrete eatecholamines, and(More)
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