Shepard Smithline

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1NASA Goddard Space Flight Center, Greenbelt, MD 20771, U.S.A. 2Princeton University, 201 Forrestal Road, Princeton, NJ 08450-6646, U.S.A. 3Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, U.S.A. 4National Center for Atmospheric Research, 1850 Table Mesa Drive, Boulder, CO 80305, U.S.A. 5National Center for Environmental(More)
Chromatographic and non-chromatographic purification of biopharmaceuticals depend on the interactions between protein molecules and a solid-liquid interface. These interactions are dominated by the protein-surface properties, which are a function of protein sequence, structure, and dynamics. In addition, protein-surface properties are critical for in vivo(More)
Quantitative systems pharmacology (QSP) modeling has become increasingly important in pharmaceutical research and development, and is a powerful tool to gain mechanistic insights into the complex dynamics of biological systems in response to drug treatment. However, even once a suitable mathematical framework to describe the pathophysiology and mechanisms(More)
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