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Guidelines for the use and interpretation of assays for monitoring autophagy
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide
BackgroundRoles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid β-peptide (Aβ), elicit a release of glutamate fromExpand
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Induction of Serine Racemase by Inflammatory Stimuli Is Dependent on AP‐1
Abstract: Serine racemase (SRace) is an enzyme that catalyzes the conversion of L‐serine to pyruvate or D‐serine, an endogenous agonist for NMDA receptors. Our previous studies showed thatExpand
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Cellular calcium deficiency plays a role in neuronal death caused by proteasome inhibitors
Cytosolic Ca2+ concentration ([Ca2+]i) is reduced in cultured neurons undergoing neuronal death caused by inhibitors of the ubiquitin proteasome system. Activation of calcium entry via voltage‐gatedExpand
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Schwann cells exhibit excitotoxicity consistent with release of NMDA receptor agonists
Neurodegenerative effects of Schwann cells transplanted into the central nervous system have been observed previously. We report here that conditioned medium from Schwann cell cultures exhibitExpand
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Induction of serine racemase expression and D-serine release from microglia by secreted amyloid precursor protein (sAPP).
Alzheimer's disease (AD) involves neuronal loss and reduction of synaptic density in specific brain region. Some of the neuronal deaths are associated with excitotoxicity. We previously reported thatExpand
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Schwann cell and epineural fibroblast expression of serine racemase
D-serine appears to be a natural agonist at the "glycine site" of the NMDA receptor and is created by conversion from L-serine by serine racemase. This racemase has been localized to protoplasmicExpand
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Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells
The two major intracellular protein degradation systems, the ubiquitin-proteasome system (UPS) and autophagy, work collaboratively in many biological processes including development, apoptosis,Expand
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Roles of NFκB-miR-29s-MMP-2 circuitry in experimental choroidal neovascularization
BackgroundPrevious reports have indicated that matrix metallopeptidase-2 (MMP-2) regulates angiogenic processes, which are involved in choroidal neovascularization (CNV). However, the regulation ofExpand
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